WNT10A gene is the second molecular candidate in a cohort of young Italian subjects with ectodermal derivative impairment (EDI).

This study is the first to show that, after ED1, WNT10A is the second molecular candidate for EDI in a large Italian Caucasian population. The study confirmed that Phe228Ile is the most frequent WNT10A variant in Caucasian populations, and that WNT10A mutations are associated with large variability in EDI.
PMID: 28976000 [PubMed - as supplied by publisher]

Source: Clinical Genetics - October 4, 2017 Category: Genetics & Stem Cells Authors: Guazzarotti L, Tadini G, Mancini GE, Sani I, Pisanelli S, Galderisi F, D'Auria E, Secondi R, Bottero A, Zuccotti GV Tags: Clin Genet Source Type: research