Consistent Discovery of Frequent Interval-Based Temporal Patterns in Chronic Patients ’ Data

Publication date: Available online 4 October 2017 Source:Journal of Biomedical Informatics Author(s): Alexander Shknevsky, Yuval Shahar, Robert Moskovitch Increasingly, frequent temporal patterns discovered in longitudinal patient records are proposed as features for classification and prediction, and as means to cluster patient clinical trajectories. However, to justify that, we must demonstrate that most frequent temporal patterns are indeed consistently discoverable within the records of different patient subsets within similar patient populations. We have developed several measures for the consistency of the discovery of temporal patterns. We focus on time-interval relations patterns (TIRPs) that can be discovered within different subsets of the same patient population. We expect the discovered TIRPs (1) to be frequent in each subset, (2) preserve their “local” metrics - the absolute frequency of each pattern, measured by a Proportion Test, and (3) preserve their “global” characteristics - their overall distribution, measured by a Kolmogorov-Smirnov test. We also wanted to examine the effect on consistency, over a variety of settings, of varying the minimal frequency threshold for TIRP discovery, and of using a TIRP-filtering criterion that we previously introduced, the Semantic Adjacency Criterion (SAC). We applied our methodology to three medical domains (oncology, infectious hepatitis, and diabetes). We found that, within the minimal frequency ranges we ha...

Source: Journal of Biomedical Informatics - October 5, 2017 Category: Information Technology Source Type: research