Perioperative Management of Female Hormone Medications.

CONCLUSION: Until additional studies are performed, the risks and benefits must be weighed on an individual basis with consideration of prophylaxis when a decision is made to continue these medications in the perioperative period. Part of this decision making includes the risk of fetal harm in an unwanted pregnancy in preparation for nonobstetric surgery versus an increased risk of venous thromboembolism. PMID: 28969534 [PubMed - as supplied by publisher]
Source: Current Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Clin Pharmacol Source Type: research

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Authors: Broggi G, Piombino E, Magro G, Vecchio GM Abstract Intestinal-type adenocarcinoma is a rare primary vaginal carcinoma and considerably more uncommon than metastatic lesions which represent the most frequent malignancy at this anatomic site. Among all malignant tumors, colorectal, breast and female genital tract carcinomas have the tendency to metastasize to the vagina. As morphologic and immunohistochemical features of intestinal-type adenocarcinoma occurring primarily in the vagina are not specific, clinical and radiologic information is crucial to exclude a metastatic lesion. Herein we present a ...
Source: Pathologica - Category: Pathology Tags: Pathologica Source Type: research
Authors: Guadagno E, De Rosa G, Nappi O Abstract A national project for the quality assessment of breast immunohistochemistry, involving 155 pathology laboratories distributed all over the Italian territory ( 19 regions), was carried out. The Project lasted one year from December 2014 to December 2015 and it was strongly supported by the Italian Society of Anatomic Pathology (SIAPEC/IAP). Proficiency tests were carried out by the Nordic Immunohistochemical Quality Control (NordiQC) organization. The main aim of the project was to investigate on the general performance of immunohistochemistry (ER, PR and HER2) in th...
Source: Pathologica - Category: Pathology Tags: Pathologica Source Type: research
ConclusionIn this nationwide study, multiple sclerosis patients did not have increased cancer incidence or increased cancer-specific mortality. We observed an increased risk of malignant melanoma mainly attributed to increased risk in the first part of our study period.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionConventional MRI, diffusion weighted imaging and contrast enhanced MR images are superior to TVUS in patients with endometrial cancer and ADC values help to differentiate between normal and endometrial cancer which may replace MR contrast enhanced images.
Source: Alexandria Journal of Medicine - Category: General Medicine Source Type: research
In this study, we found that miR-542-3p was significantly downregulated in epithelial ovarian cancer (EOC) tissues and cell lines. Functional assays showed that overexpression of miR-542-3p suppressed tumor cell proliferation, migration, and invasion in vitro, whereas miR-542-3p knockdown dramatically promoted tumor cell proliferation and invasion. An in vivo assay also revealed that miR-542-3p overexpression significantly attenuated tumor growth. Mechanistically, the gene of cyclin-dependent kinase 14 (CDK14) was identified as a novel target of miR-542-3p. CDK14 overexpression reversed the suppressive effects of miR-542-3...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Conclusions: Our study demonstrates that NCH gel appears to be able to reduce the formation of IUAs in women who undergo curettage in the second trimester, although larger controlled, randomized, multicenter studies are needed to confirm these results. PMID: 30524185 [PubMed - in process]
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - Category: Surgery Tags: JSLS Source Type: research
In conclusion, trial recruitment – requiring both geriatric as well as molecular eligibility criteria – proved more difficult than expected. Bearing in mind the very small sample size, upfront cetuximab treatment appeared tolerable and showed promising activity in left-sided tumors in both treatment arms.
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 14 December 2018Source: Trends in Anaesthesia and Critical CareAuthor(s): Yavor Metodiev, Mary Mushambi, S.M. Kinsella
Source: Trends in Anaesthesia and Critical Care - Category: Anesthesiology Source Type: research
Publication date: Available online 15 December 2018Source: Anaesthesia &Intensive Care MedicineAuthor(s): David J. ChambersAbstractIntravenous infusions are required when a drug has a short half-life or a narrow therapeutic window. Pharmacokinetic models are employed to calculate the infusion rate for a particular target plasma concentration. While the one-compartment model is based on relatively simple mathematics, it is of little practical use. Multi-compartment models involve complex mathematics: a bolus-infusion regimen requires a variable-infusion rate. In clinical practice, this means incorporating the pharmacoki...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
This article discusses consent, and its refusal, to medical interventions by children and adolescents.
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
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