Complicated Recovery Awaits Victims Injured in Vegas Attack

LAS VEGAS (AP) — Their concert turned into a siege, and now their lives may become a battle. The staggering count of people injured in the shooting at a Las Vegas music festival means their recoveries are likely to be as varied as the victims themselves. Some injuries are as simple as broken bones, others gunshot wounds involving multiple surgeries and potential transplants, and all come with the added emotional scars of enduring the deadliest shooting in modern U.S. history, with 59 killed. At least 130 people remained hospitalized Tuesday, with 48 listed in critical condition. Hospitals said 185 others had already been released. At Sunrise Hospital and Medical Center alone, the count of those treated included 120 people who were struck by gunfire, a glimpse of the amount of ammunition unleashed in the attack. Rehabilitation for the most seriously hurt victims will take far longer than many may realize. "Years," said Dr. Thomas Scalea, physician-in-chief at the University of Maryland's Shock Trauma Center in Baltimore, one of the nation's largest trauma centers. "It's not days or weeks." Edward Leon raced to Las Vegas from Palm Springs, California, after learning his niece was shot in the stomach. He said he cried the whole way there. Although she survived an initial operation, he worries about what will come next. "She's out of surgery," he said, "but it's a long road ahead." At the site of the attack, people fashioned stretcher...
Source: JEMS Patient Care - Category: Emergency Medicine Authors: Tags: Major Incidents News Mass Casualty Incidents Patient Care Source Type: news

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We report that the disruption of excitation-contraction coupling contributes to impaired force generation in the mouse model of Sod1 deficiency. Briefly, we found a significant reduction in sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity as well as reduced expression of proteins involved in calcium release and force generation. Another potential factor involved in EC uncoupling in Sod1-/- mice is oxidative damage to proteins involved in the contractile response. In summary, this study provides strong support for the coupling between increased oxidative stress and disruption of cellular excitation contraction mac...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
With the development of medical technology, transplantation has prevailed and become an important tool in the treatment of disease. According to the WHO ’s statistics, as of 2015, approximately 120000 cases of solid organ transplantation have been performed globally. Renal transplantation is the most common, followed by liver transplantation, heart transplantation, lung transplantation, hematopoietic stem cell transplantation, etc. [1]. And, in re cipients of transplantation, seizures usually occur during the postoperative period [2,3].
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Tags: Review Source Type: research
Purpose of review Telomere attrition has been proposed as one of the aging hallmarks in pulmonary fibrosis. Telomere shortening and telomerase gene mutations have been widely evaluated in recent years. Reduced telomere length may be identified in a quarter of patients with sporadic idiopathic pulmonary fibrosis (IPF) and half of those cases with family aggregation. However, telomere studies have not transferred from the research field to the clinic. This review is focused on our current understanding of the pathogenic implication of telomere dysfunction in lung fibrosis and its relevance in the clinical setting. Recent ...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: INTERSTITIAL LUNG DISEASE: Edited by Francesco Bonella and Paolo Spagnolo Source Type: research
Background: Organ transplant recipients experience increased skin cancer rates secondary to their immunosuppressive regimens. These impacts on skin cancer rates occur within individual patient risk-profiles, which include factors such as skin tone. We sought to compare the rates of skin cancer development in a cohort of Caucasian and non-Caucasian liver and lung transplant recipients to better elucidate the protective effect of darker skin tone on post-transplantation skin cancer development.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
n R Abstract PURPOSE OF REVIEW: The long-term adverse effects of immunosuppressive treatment, the high rate of acute rejection and the development of chronic rejection are the main factors preventing a wider clinical application of vascularized composite allotransplantation (VCA). Targeted immunosuppression using innovative drug delivery systems (DDS) may help to overcome these hurdles, increasing therapeutic efficacy while reducing systemic toxicity. This review provides a summary of the recently developed strategies for targeted delivery of immunosuppressive drugs in VCA. RECENT FINDINGS: Currently, several...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
Pediatric Transplantation, EarlyView.
Source: Pediatric Transplantation - Category: Transplant Surgery Authors: Source Type: research
Semin Liver Dis 2018; 38: 284-297 DOI: 10.1055/s-0038-1666853Sarcoidosis is a multisystem inflammatory disease, which is characterized by the development of noncaseating granulomas amid healthy tissue. While most commonly affecting the mediastinum and/or lungs, sarcoid can also affect the liver, resulting in “hepatic sarcoid.” The spectrum of disease in hepatic sarcoid is variable, ranging from asymptomatic or mild liver enzyme abnormalities to end-stage liver disease requiring liver transplantation. Because clinically-significant hepatic sarcoid is rare, research on epidemiology, clinical manifestations, and t...
Source: Seminars in Liver Disease - Category: Gastroenterology Authors: Tags: Review Article Source Type: research
Abstract BACKGROUND Donor hypernatremia has been associated with reduced graft and recipient survival after heart, liver, kidney, and pancreas transplantation. However, it is unknown what effect donor hypernatremia has on graft and recipient outcomes after lung transplantation. The aim of this study was to investigate the relation of donor hypernatremia with the duration of postoperative mechanical ventilation, the incidence of severe primary graft dysfunction, and survival following lung transplantation. MATERIAL AND METHODS We analyzed all consecutive lung transplantations performed in adult patients at our cent...
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractRespiratory-gated18F-fluorodeoxygluocse (18F-FDG) PET/CT has been successfully used to better localize malignancies in the lung or upper abdominal organs. However, clinical usefulness of respiratory-gated18F-FDG PET/CT in detection of fever focus has not been reported yet. A 68-year-old male patient with a history of living donor liver transplantation and biliary stenting was referred for18F-FDG PET/CT due to fever of unknown origin (FUO). To find the accurate fever focus, respiratory-gated and non-gated18F-FDG PET/CT was performed. Respiratory-gated PET/CT readily revealed prominent hypermetabolic lesion in the di...
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
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