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Development of progressive hearing loss and tinnitus in a patient with myasthenia gravis: an overlooked comorbidity?

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Source: Hearing, Balance and Communication - Category: Audiology Authors: Source Type: research

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Authors: Takahashi Y, Yamashita T, Morihara R, Nakano Y, Sato K, Takemoto M, Hishikawa N, Ohta Y, Hayata K, Masuyama H, Okamura T, Washio Y, Abe K Abstract We herein report the case of a 46-year-old pregnant woman with anti-muscle specific kinase (MuSK) antibody-positive myasthenia gravis (MG) who showed pregnancy-induced hypertension and developed respiratory failure at 30 weeks and 5 days of pregnancy, and who underwent an emergency caesarean section (CS). Her MG symptoms gradually improved in the subsequent weeks. The premature baby with positive MuSK antibodies was successfully delivered, but the male baby requ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
AbstractThe incidence of blast injury has increased recently. As the ear is the organ most sensitive to blast overpressure, the most frequent injuries seen after blast exposure are those affecting the ear. Blast overpressure affecting the ear results in sensorineural hearing loss, which is untreatable and often associated with a decline in the quality of life. Here, we review recent cases of blast-induced hearing dysfunction. The tympanic membrane is particularly sensitive to blast pressure waves, since such waves exert forces mainly at air –tissue interfaces within the body. However, treatment of tympanic membrane p...
Source: Journal of Zhejiang University. Science. B. - Category: Universities & Medical Training Source Type: research
Guidelines exist for evaluation and management of tinnitus in adults; however lack of evidence in children limits applicability of these guidelines to pediatric patients. Objective of this study is to determine the incidence of inner ear anomalies detected on imaging studies within the pediatric population with tinnitus and evaluate if presence of hearing loss increases the rate of detection of anomalies in comparison to normal hearing patients.
Source: International Journal of Pediatric Otorhinolaryngology - Category: ENT & OMF Authors: Source Type: research
We present the case of a 46 year old female that presented with right tinnitus, dizziness and bifrontal headache, progressive, starting two years before. Imaging studies reveals an incidentally neoplastic extraaxial homogeneous appearance tumor on the right anterior skull base. She undewernt surgical treatment with total resection of the tumor by a bicoronal approach. The histopathological study reported schwannoma.Although attributte the origin of schwannomas from the the olfactory nerve is near impossible, once they do not have Schwann cells, intracranial supratentorial schwannomas are mainly located in the anterior skull base.
Source: World Neurosurgery - Category: Neurosurgery Authors: Tags: Case Report Source Type: research
A 20-year-old man presented with bilateral fatigable ptosis for 1 month. On examination, there was bilateral incomplete ptosis, which deteriorated during upward gaze and improved at rest (figure, A and B). Tests for myasthenia gravis were all negative. Brain MRI showed symmetric hyperintensities at periaqueductal gray matter on T2- and diffusion-weighted images (figure, C). CSF lactic acid was elevated. Mitochondrial genome test demonstrated a homoplasmic T9176C mutation in the MT-APT6A gene, known as pathogenic mutation of Leigh syndrome.1 In our patient, fatigable ptosis may be ascribed to the dysfunction at centrally lo...
Source: Neurology - Category: Neurology Authors: Tags: MRI, Eyelids, Mitochondrial disorders NEUROIMAGES Source Type: research
Publication date: November 2017 Source:Journal of Clinical Neuroscience, Volume 45 Author(s): Ren-Jun Hsu, Chien-Yu Lin, Fung-Wei Chang, Chun-Fa Huang, Heng-Chang Chuang, Jui-Ming Liu Scabies is an infectious inflammatory pruritic skin disease. Cytokine-mediated inflammatory processes contribute to the pathologic mechanism in scabies. Myasthenia gravis (MG) is also an autoimmune disease that is mediated by cytokines. The study aimed to investigate the association between scabies and myasthenia gravis. We conducted a nationwide population-based cohort study utilized data from the National Health Insurance Research Database...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Abstract Myasthenia gravis (MG) is an autoimmune disease caused by sensitization of the immune system to self-antigens. We have previously shown that targeting MG-susceptible alleles can significantly inhibit proliferation of disease-specific T cells. In this work, we humanized a murine monoclonal antibody (mAb) LG11, capable of blocking MG-associated DQ beta 1 (DQB1) allele and reformatted it into single-chain fragment variable (scFv). A fully functional humanized scFv was obtained by optimizing variable domain orientations and linker lengths, along with the optimization of expression conditions and codons to sui...
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Tags: Appl Microbiol Biotechnol Source Type: research
Publication date: Available online 5 October 2017 Source:Brain Stimulation Author(s): Christian Plewnia
Source: Brain Stimulation - Category: Neurology Source Type: research
Conclusions: One incident EOI of asthma late in the 1-year observation period and sporadic distribution of SMAEs were observed. These data do not suggest safety concerns associated with MenACWY-CRM vaccination in children 2–10 years old.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Vaccine Reports Source Type: research
Condition:   Tinnitus Interventions:   Device: tDCS;   Device: rTMS Sponsor:   University of Arkansas Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Audiology | Myasthenia Gravis | Tinnitus