New organotin supramolecular complexes based on copper cyanide and auxiliary N ‐donor ligands as potent inhibitors of cancer cell lines: In vitro and antioxidant experiments

The new synthesized supramolecular complexes (SC); [Cu2(CN)4(Et3Sn)2(tbpe)], 1 and [Cu2(CN)3(Et3Sn)(bpe)], 2 (tbpe = trans‐1,2‐bis(4‐pyridyl)ethene and bpe = 1,2‐bis(4‐pyridyl)ethane), were characterized by elemental analyses, electrical conductance, spectroscopic studies and thermal analyses. UV–Vis spectra and magnetic moment data suggested the tetrahedral geometry around Cu(I) atoms. The structures of the SC 1 and 2 were also theoretically studied using molecular mechanics (MM+). The structures were minimized with a semi‐empirical (PM3) method. The organotin compounds represent significant advances in the clinical management of some cancer cell lines. 1 and 2 were tested as inhibitors and their citotoxicities showed potent growth inhibitory activity for hepatocellular carcinoma HePG‐2, mammary gland breast cancer MCF‐7, human prostate cancer PC3 and Colorectal carcinoma HCT‐116 cell lines. The tested compounds showed high inhibitory anti‐oxidant activity either using erythrocyte hemolysis or ABTS method. Structures of the SC 1 (a) and 2 (b). New synthesized supramolecular complexes (SC); [Cu2(CN)4(Et3Sn)2(tbpe)], 1 and [Cu2(CN)3(Et3Sn)(bpe)], 2 have been synthesized and characterized structurally. The structures extend to form 3D‐ network via the (CN–Ete3Sn–CN) spacers and the tbpe or bpe ligand as connecting units as well as H‐bonds. The structures of the SC 1 and 2 were also theoretically studied using molecular mechanics (MM+). 1 and 2...
Source: Applied Organometallic Chemistry - Category: Chemistry Authors: Tags: FULL PAPER Source Type: research