Traditional Long-Term Central Venous Catheters Versus Transhepatic Venous Catheters in Infants and Young Children
Conclusions: Without compromising future central venous access sites, transhepatic venous lines had superior duration of service without increased thrombosis, thrombolytic use, or insertion site complications relative to central venous lines. Transhepatic venous catheters had a higher infection rate, and further investigation into the etiology is warranted.
To determine thrombosis incidence, morbidities, and mortality of children with congenital heart disease who develop thrombosis after cardiac surgery.
CONCLUSIONS: In a community-based sample of Japanese men free of CHD and stroke, CAC score ≥100 was significantly associated with higher estimated CHD risk by prediction models. This finding supports the potential utility of CAC as a biomarker for CHD in a general Japanese male population. PMID: 29212987 [PubMed - as supplied by publisher]
Conclusions The SMART-CHOICE trial aims to examine the non-inferiority of monotherapy with one of any available oral P2Y12 inhibitors versus conventional DAPT of an identical P2Y12 inhibitor plus aspirin in a broad spectrum of patients receiving representative current-generation DES.
ConclusionsAmong patients with stable angina or silent ischemia, there was no difference between UFH and bivalirudin in bleeding rates up to 30‐days post‐PCI. MACCE and NACE were higher among the bivalirudin group. Radial access was associated with a numerically lower rate of bleeding compared with femoral access.
Abstract Heparin‐induced thrombocytopenia (HIT) is a life‐threatening complication of heparin therapy. The risk for HIT correlates with the cumulative dosage of heparin exposure. In Fontan patients, recurrent systemic anticoagulation, traditionally with heparin, is used to alleviate the thrombotic complications that may occur postoperatively when the venous pressure rises and the systemic venous flow into the pulmonary arteries becomes sluggish, putting them at increased risk. As a pressure gradient‐dependent circulation, elevation in systemic venous pressure, most often by venous thrombosis, contributes to circuit f...
CONCLUSIONS: Rosuvastatin protected SR-B1(-/)(-)/apoE(-/)(-) mice against atherosclerosis and platelet accumulation in coronary arteries and attenuated myocardial fibrosis and cardiomegaly, despite increased plasma total cholesterol. The ability of rosuvastatin to reduce oxidized phospholipids in atherosclerotic plaques and inhibit macrophage foam cell formation may have contributed to this protection. PMID: 29162602 [PubMed - as supplied by publisher]
This study describes the clinical and neuroimaging characteristics of CSVT in neonates undergoing cardiac surgery.
CONCLUSIONS: Results support the importance of the F7 and PROCR loci on variation in circulating FVIIa and FVIIa-AT. Findings suggest FVIIa is a risk factor for ischemic stroke in older adults while higher FVIIa-AT may reflect mortality risk. This article is protected by copyright. All rights reserved. PMID: 29112333 [PubMed - as supplied by publisher]
CONCLUSIONS: The rs12740374 minor allele sequence enhances SORT1 expression in hepatocytes. CRISPR-Cas9 can be used in primary human hepatocytes ex vivo and locus-humanized mice in vivo to interrogate the function of noncoding regulatory regions. induced pluripotent stem cell-derived hepatocyte-like cells experience limitations that prevent faithful modelling of some hepatocyte expression quantitative trait locus. PMID: 29097363 [PubMed - as supplied by publisher]
ConclusionsResults support the importance of the F7 and PROCR loci on variation in circulating FVIIa and FVIIa‐AT. Findings suggest FVIIa is a risk factor for ischemic stroke in older adults while higher FVIIa‐AT may reflect mortality risk.This article is protected by copyright. All rights reserved.