Traditional Long-Term Central Venous Catheters Versus Transhepatic Venous Catheters in Infants and Young Children

Conclusions: Without compromising future central venous access sites, transhepatic venous lines had superior duration of service without increased thrombosis, thrombolytic use, or insertion site complications relative to central venous lines. Transhepatic venous catheters had a higher infection rate, and further investigation into the etiology is warranted.
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research

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CONCLUSIONS: Only 25.1% of patients in our study achieved good INR control, despite regular INR monitoring. There is an urgent need to improve anticoagulation control of patients receiving warfarin in SA. Validated dosing algorithms are required, and access to lower warfarin dosage formulations may optimise individual dose titration. Advocacy for these formulations is advised. PMID: 30004329 [PubMed - in process]
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
Vascular endothelial injury (VEI) triggers pathological processes in various cardiovascular diseases, such as coronary heart disease and hypertension. To further elucidate the in vivo pathological mechanisms of VEI, many animal models have been established. For the easiness of genetic manipulation and feeding, murine models become most commonly applied for investigating VEI. Subsequently, countless valuable information concerning pathogenesis has been obtained and therapeutic strategies for VEI have been developed.
Source: Thrombosis Research - Category: Hematology Authors: Tags: Review Article Source Type: research
CONCLUSIONS: HDL cell-cholesterol efflux capacity is significantly influenced by both the concentration and the functionality of specific HDL particles participating in cell-cholesterol efflux. Coronary heart disease patients have higher than normal preβ-1 concentrations with decreased functionality and lower than normal large HDL particle concentrations with enhanced functionality. PMID: 30002062 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
This article discussed the appropriate antithrombotic therapy when balancing the effectiveness and the risk in different circumstance of concurrence of VTE and CHD, such as combining anticoagulation therapy, dual antiplatelet therapy (DAPT), triple antithrombotic therapy (TAT), thrombolytic therapy and extending therapy, in order to provide safe, standard and effective therapeutic schemes for the clinical management of these patients. In the meantime, this article also provides perspectives regarding the application of novel non-vitamin K anticoagulants (NOACs) and the assessment tools of bleeding risk.
Source: Chinese Medical Sciences Journal - Category: General Medicine Source Type: research
Publication date: Available online 13 June 2018Source: Journal of Cardiology CasesAuthor(s): Laura Leticia Rodríguez-Chávez, Grecia Iveth Maryelis Raymundo-Martínez, Rodrigo Gopar-NietoAbstractThere is no report of four valve replacement surgeries in a woman during 15-year follow-up. A 23-year-old female was diagnosed at 7 years with rheumatic fever. She developed severe mitral regurgitation and at the same age a prosthetic valve was placed. In the next 15 years her mitral valve was changed 3 times because of clinical, echocardiographic, and histopathologic evidence of thrombosis. Her coagulation tests...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Publication date: Available online 19 May 2018Source: Indian Heart JournalAuthor(s): P.C. Negi, Sachin Sondhi, Vivek Rana, Sanjay Rathoure, Ravi Kumar, Nirmal Kolte, Ritesh Kumar, Shivani Rao, Ashish Diman, Kunal Mahajan, Munish Dev, Arvind Kandoria, Neeraj Ganju, Rajeev Bhardwaj, Rajeev Merwaha, Rajesh Sharma, Sanjeev AsotraAbstractObjectiveTo report the prevalence, risk factors and consequences of atrial fibrillation (AF) in patients of rheumatic heart disease (RHD).MethodsThe Himachal Pradesh- Rheumatic Fever/Rheumatic Heart Disease (HP-RF/RHD) Registry database of 1918 patients was analyzed. AF was diagnosed with 12-le...
Source: Indian Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 20 September 2017Source: Cor et VasaAuthor(s): Jan Hulka, Jiri SoukupAbstractTakotsubo cardiomyopathy (TTC) belongs to rare heart disease with symptoms imitating acute coronary syndrome with ST segment elevation. Usually, it occurs predominantly in postmenopausal women. In most cases, the disease has an uncomplicated course, but some patients may develop severe complications (e.g. cardiogenic shock, severe heart failure, malignant arrhythmia, thromboembolism or myocardial wall rupture). This case report describes an 82-year-old man with TTC complicated rupture of the left ventricular free...
Source: Cor et Vasa - Category: Cardiology Source Type: research
ConclusionPatients with CHD—both cyanotic and acyanotic—have variable degrees of increased liability for both thrombosis and hemorrhage that represents some sort of adaptation to preserve hemostasis and to protect these patients against the clinical presentation of both thrombosis and bleeding. This is to say that CHD patients have their own point of balance between thrombogenicity and bleeding liability. Wide-scale studies are needed to detect the normal levels of different thrombohemorrhagic parameters of these patients.
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research
Publication date: June 2018Source: Anaesthesia &Intensive Care Medicine, Volume 19, Issue 6Author(s): Jonathan Weale, Andrea A. KelleherAbstractContinued advances in the understanding and management of congenital heart disease (CHD) mean that over 90% of children born with CHD now survive to adulthood. This in turn results in greater numbers of adult patients presenting for medical and surgical care at non-specialist centres. A simple classification of adult congenital heart disease (ACHD) according to complexity can help clinicians to understand the implications of the specific cardiac anomaly encountered. Issues rela...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
This article discussed the appropriate antithrombotic therapy when balancing the effectiveness and the risk in different circumstance of concurrence of VTE and CHD, such as combining anticoagulation therapy, dual antiplatelet therapy (DAPT), triple antithrombotic therapy (TAT), thrombolytic therapy and extending therapy, in order to provide safe, standard and effective therapeutic schemes for the clinical management of these patients. In the meantime, this article also provides perspectives regarding the application of novel non-vitamin K anticoagulants (NOACs) and the assessment tools of bleeding risk.
Source: Chinese Medical Sciences Journal - Category: General Medicine Source Type: research
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