Heat shock protein 70 of Trypanosoma evansi is phylogenitically closer to salivaria than stercoraria homologs

AbstractTrypanosomioisis is an economically significant disease affecting a wide range of animals in tropics and subtropics. Heat shock proteins (HSPs) play an important role in trypanosomes by altering parasite ’s physiology and adaptability as its life cycle alternates between the poikilothermic invertebrate vector and the homoeothermic vertebrate hosts. The aim of the present study was find out the phylogenetic relationship betweenT. evansi and other trypanosomes usingHSP 70 gene.HSP 70 ofTrypanosoma evansi was cloned, characterized, and phylogenitically analyzed withHSP 70 sequences of other trypanosomes. Results revealed thatHSP 70 is a highly conserved molecule in trypanosomes. It showed 100% identity with other sequences ofT. evansi andT. equiperdum. Alongside, it showed much higher identities with sequences of trypanosomes of anterior station group than those of posterior station group. Hence, it was concluded thatHSP 70 ofT. evansi is phylogenitically closer to salivaria than stercoraria homologs. The finding is important from evolutionary point of view.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

Related Links:

Parasites genes prepare it for the unexpected, but could be exploited to fight the disease More at https://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=299535&WT.mc_id=USNSF_1 This is a Research News item.
Source: NSF Discoveries - Category: Science Source Type: research
In conclusion, the serodiagnostic assays evaluated in this study are useful for the detection of ascarid infections in chickens.Graphical abstract
Source: Parasitology International - Category: Parasitology Source Type: research
Abstract Folates are essential biomolecules required to carry out many crucial processes in leishmania parasite. Dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) involved in folate biosynthesis in leishmania have been established as suitable targets for development of chemotherapy against leishmaniasis. In the present study, various computational tools such as homology modelling, pharmacophore modelling, docking, molecular dynamics and molecular mechanics have been employed to design dual DHFR-TS and PTR1 inhibitors. Two designed molecules, i.e. 2-(4-((4-nitrobenzyl)oxy)pheny...
Source: SAR and QSAR in Environmental Research - Category: Environmental Health Authors: Tags: SAR QSAR Environ Res Source Type: research
Publication date: Available online 8 November 2019Source: Protein Expression and PurificationAuthor(s): B.O. Araujo-Montoya, M.R. Senger, B.F. Gomes, G. Harris, R.J. Owens, F.P. Silva-JrAbstractSchistosomes express a variety of aspartyl proteases (APs) with distinct roles in the helminth pathophysiology, among which degradation of host haemoglobin is key, since it is the main amino acid source for these parasites. A cathepsin D-like AP from Schistosoma mansoni (SmCD1) has been used as a model enzyme for vaccine and drug development studies in schistosomes and yet a reliable expression system for readily producing the recom...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Publication date: Available online 9 November 2019Source: Molecular and Biochemical ParasitologyAuthor(s): Víctor Caña-Bozada, F. Neptalí Morales-Serna, Alejandra García-Gasca, Raúl Llera-Herrera, Emma J. Fajer-ÁvilaAbstractATP-Binding Cassette (ABC) transporters are proteins that actively mediate the transport of a wide variety of molecules, including drugs. Thus, in parasitology, ABC transporters have gained attention as potential targets for therapeutic drugs. Among the parasitic Platyhelminthes, ABC transporters have been identified and classified in a few species of Trematoda ...
Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research
In conclusion, this reduced establishment rate was associated with an increased production of eggs by the female parasites and suggested a phenomenon of density-dependent prolificacy of H. contortus probably inherent to the fitness of the parasite population.
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Publication date: Available online 8 November 2019Source: MicronAuthor(s): Isaac Filipe Moreira Konig, Marcos Vinícius Silva de Oliveira, Raquel Romano Palmeira Gonçalves, Ana Paula Peconick, Sérgio Scherrer Thomasi, Luís Adriano Anholeto, José Ribamar Lima-de-Souza, Maria Izabel Camargo-Mathias, Rafael Neodini RemedioAbstractRhipicephalus sanguineus sensu lato (s. l.) ticks are targets of acaricidal treatments due to their great veterinary and medical importance. Acetylcarvacrol stands out as a promising acaricidal substance for its increased biocidal activity and stability. Additionally...
Source: Micron - Category: Biology Source Type: research
Publication date: Available online 8 November 2019Source: Pesticide Biochemistry and PhysiologyAuthor(s): Elodie Peghaire, Anne Moné, Frédéric Delbac, Didier Debroas, Frédérique Chaucheyras-Durand, Hicham El AlaouiAbstractHoneybees ensure a key ecosystemic service by pollinating many agricultural crops and wild plants. However, since few decades, managed bee colonies have declined worldwide. This phenomenon is considered to be multifactorial, with a strong emphasis on both parasites and pesticides. Infection by the parasite Nosema ceranae and exposure to pesticides can contribute to adver...
Source: Pesticide Biochemistry and Physiology - Category: Biochemistry Source Type: research
AbstractCystic echinococcosis is a potential zoonotic helminthic disease affect a broad spectrum of mammals including humans worldwide. The economic impact of the disease interestingly requires updated gathering information on the prevalence in slaughtered animals. Accordingly, in the current study, 573 camels, 4300 sheep, and 1235 pigs were surveyed in four Egyptian municipal abattoirs. Among those, 62 (10.82%) camels, 33 (0.77%) sheep and 3 (0.24%) pigs had cystic echinococcosis in lungs, livers and spleen. The diversity of cysts revealed that positive-cystic echinococcosis animals from all species were detected in El-Ba...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
In conclusion, all extracts and petroleum ether extracts of the two plants have great potential to be developed as a novel acaricidal for controlling eggs and nymphs ofH. dromedarii, respectively.
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
More News: Genetics | Parasitic Diseases | Parasitology | Pathology | Physiology | Study