Effects of endogenous hypercortisolism on bone mRNA and microRNA expression in humans

ConclusionsAn excess of endogenous GC in humans suppresses bone formation through the upregulation of Wnt-signaling antagonists and dysregulation of miRs involved in mesenchymal stem-cell commitment. Both Wnt-signaling antagonists and miRs seem to be promising targets for further research in therapeutic intervention in glucocorticoid-induced osteoporosis.

http://link.springer.com/10.1007/s00198-017-4241-7

Source: Osteoporosis International - October 4, 2017 Category: Orthopaedics Source Type: research