Cast nephropathy and deceptively low absolute serum free light chain levels: resolution of a challenging case and systematic review of the literature

Multiple myeloma (MM) is a hematological malignancy characterized by the accumulation of monoclonal plasma cells (PCs) in the bone marrow (BM). Monoclonal PC proliferation is accompanied by the secretion of a monoclonal protein that serves as a quantitative MM marker and can be detected in the blood and/or urine. The International Myeloma Working Group defined the diagnostic criteria for symptomatic MM, smouldering MM and monoclonal gammopathy of undetermined significance based on biological parameters and presence of clinical symptoms.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research