Ketamine Found to Reduce Suicidal Thoughts in Depressed Patients

A single infusion of ketamine appears to significantly reduce suicidal thoughts in depressed patients in as little as one day, with benefits lasting for up to one week, according to ameta-analysis reported inAJP in Advance. Moreover, although change in severity of depressive symptoms was strongly correlated with change in suicidal ideation, after controlling for improvement in severity of depressive symptoms, ketamine ’s effects on suicidal ideation remained significant. “This suggests that ketamine has a specific effect on suicidal ideation that depends only partly on change in overall severity of depressive symptoms,” Samuel T. Wilkinson, M.D., of the Department of Psychiatry and the Child Study Center at Yale School of Medicine and colleagues wrote.Wilkinson and colleagues searched MEDLINE using the terms “ketamine,” “NMDA receptor antagonist,” “ketamine-like,” or “rapid antidepressant” and “suicide,” “suicidality,” or “suicidal ideation” for articles published between Jan. 1, 2000, and Nov. 15, 2016. Eleven eligible trials were identified from 153 citations, and correspon ding authors provided individual subject data on 298 patients who participated in the 10 included ketamine trials; patients in the control arm of the trials received either saline or midazolam, which is used as a preoperative sedative.A total of 167 patients met criteria for baseline suicidal ideation. Ketamine reduced suicidal ideation more rapidly than was ob...
Source: Psychiatr News - Category: Psychiatry Tags: independent effect on suicidality ketamine major depression suicide Source Type: research