Tyroscherin and tyroscherin analogs from Pseudallescheria boydii SNB-CN85 isolated from termite Termes cf. hispaniolae

Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Jonathan Sorres, Charlotte Nirma, Morgane Barthélemy, Véronique Eparvier, Didier Stien Two new tyroscherin derivatives: N-methyl-tyroscherone (2) and tyroscherin N,O-acetonide (3), as well as two known secondary metabolites tyroscherin (1) and pseurotin A (4), were isolated from a solid culture of the termite-borne fungus Pseudallescheria boydii SNB-CN85. The structures were elucidated by spectroscopic analysis and chemical modification. Compound 3 was synthesized from tyroscherin (1) in the free amine form by heating in deuterated acetone, followed by deuterium-proton exchange in MeOH. All compounds were tested for their antimicrobial activities on C. albicans and S. aureus, and 2 and 3 exhibited minimal inhibitory concentrations between 128 and 8μgmL−1. Graphical abstract

Source: Phytochemistry Letters - October 3, 2017 Category: Chemistry Source Type: research