Three new triterpenoid saponins from the aerial parts of Lysimachia foenum-graecum

Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Lu-Mei Dai, Ri-Zhen Huang, Bin Zhang, Jing Hua, Hai-Bing Liao, Heng-Shan Wang, Dong Liang A further phytochemical investigation of the aerial parts of Lysimachia foenum-graecum Hance led to the isolation of three new oleanane-type triterpenoid saponins, foegraecumosides L–N (1–3), along with one known saponin, 3-O-β-d-glucopyranosyl-(1→2)-α-l-arabinopyranosyl-cyclamiretin A (4). Their structures were elucidated by spectroscopic data analyses and chemical methods Compounds 1−4 were evaluated for their cytotoxicity against NCI-H460, MGC-803, HepG2, and T24 human cancer cell lines, and compound 4 showed moderate activity against all tested cell lines. Furthermore, the cytotoxicity of compound 4 was tested on drug-sensitive and drug-resistant lung cancer cell lines (A549 and A549/CDDP, respectively). Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research