Nonimmune hydrops fetalis due to autosomal recessive hereditary spherocytosis
Conclusion The case highlights the importance of considering less common genetic mutations involving the RBC structural proteins when patients present with severe fetal anemia and nonimmune hydrops fetalis.
Condition: Cancer Anaemia Intervention: Drug: Ferinject Sponsor: Samsung Medical Center Recruiting
Conclusion: TfR2 -Y250X and TfR1-rs3817672 SNP showed clinical association with iron deficiency anemia and screening for mutations of TFR2 is a new diagnostic tool that can be offered to patients who do not have HFE mutations or who have incomplete HFE genotypes. This results may have practical implications for the molecular diagnosis of hemochromatosis. Genotyping the TFR gene should be included in the disease diagnostic protocols. PMID: 31793267 [PubMed - in process]
We examined a patient aged 31 who had a sudden burning paraesthesia, pain and numbness in the lower legs together with an increased temperature of 39°C. Clinical examination showed asymmetrical sensory polyneuropathy more clearly seen in the lower legs and the left wrist, with high ESR (up to 44 mm/h), leukocytosis, slight anemia and proteinuria. CSF was normal. After three weeks the temperature suddenly increased again up to 39°C and severe flaccid distal tetraparesis was seen more clearly with foot drop in the left lower leg and dense oedema in the left wrist, purple cyanosis and haemorrhagic foci appeared on the...
ConclusionsCompared to other pituitary adenomas, secreting and non-secreting, where pituitary surgery is the recommended first-line treatment, men with prolactinomas will usually respond to medical treatment with no need for any additional treatment.
Publication date: Available online 4 December 2019Source: Revista Clínica Española (English Edition)Author(s): Á. Torralba-Morón, J.M. Guerra-Vales, F.J. Medrano-Ortega, M.A. Navarro-Puerto, D. Lora-Pablos, I. Marín-León, E. Calderón-Sandubete, A. Gómez-de la CámaraAbstractBackground and objectivesHeart failure (HF) is a frequent condition that deteriorates quality of life and results in high morbidity and mortality. A considerable number of studies have been implemented in recent years to determine the factors that affect the prognosis of HF; however, few stud...
ConclusionLaparoscopic resection of bleeding HCC is achievable and can be considered in the treatment algorithm of selected patients.
CONCLUSION: Duration of AA, ANC and decreased ALC rate after IST might predict the response to IST, among which the rate of decreased ALC after IST is the most important predictive factor. PMID: 31793407 [PubMed - in process]
Conclusion: Hereditary spherocytosis patients should be followed closely in terms of development, puberty, bone health as they are in other hemolytic anemias. Nutritional recommendations, vitamin D supplementation, physical activity should be advised to protect bone health. PMID: 31793406 [PubMed - in process]
This study also included a control group of 231 age-compatible non-pregnant women. Women who met the international criteria for diagnosing the syndrome filled in a sociodemographic questionnaire.Results. A statistically significant association between the existence of iron deficiency anemia and RLS in the sample of the examined women was proven (p
Publication date: December 2019Source: Fish &Shellfish Immunology, Volume 95Author(s): Wilson Gómez Manrique, Mayra Araguaia Pereira Figueiredo, Ives Charlie-Silva, Marco Antonio de Andrade Belo, Cristina Corsi DibAbstractIn order to understand the pathophysiology of melanomcrophage centers (MMCs) formation during the tilapia defense response to bacterial infections, the present study evaluated the response, in terms of area, number and pigment constitution, of splenic MMCs of Oreochromis niloticus subjected to intraperitoneal (i.p.) infection with Aeromonas hydrophila and Mycobacterium marinum. Eighty-four fish...