Antibody-associated CNS syndromes without signs of inflammation in the elderly

Conclusions:
In patients ≥60 years of age, the correct identification of characteristic CNS syndromes (FBDS, anti-IgLON5 syndrome, AE) should prompt antibody testing even without evidence of inflammation in MRI and CSF studies. Up to 15% of the patients developed rapidly progressive cognitive deterioration, which further complicated the differential diagnosis with a neurodegenerative disorder.

Source: Neurology - October 2, 2017 Category: Neurology Authors: Escudero, D., Guasp, M., Arino, H., Gaig, C., Martinez-Hernandez, E., Dalmau, J., Graus, F. Tags: Autoimmune diseases, Encephalitis, All Clinical Neurology, All Epilepsy/Seizures ARTICLE Source Type: research