Intracoronary delivery of recombinant TIMP-3 after myocardial infarction: effects on myocardial remodeling and function

This study is the first to demonstrate that a relevant delivery approach (intracoronary) using rTIMP can alter the course of post-MI remodeling.
NEW & NOTEWORTHY Myocardial ischemia and reperfusion injury remain significant causes of morbidity and mortality whereby alterations in the balance between matrix metalloproteinase and tissue inhibitor of metalloproteinase have been identified as contributory biological mechanisms. This novel translational study advances the concept of targeted delivery of recombinant proteins to modify adverse myocardial remodeling in ischemia-reperfusion injury.

Source: AJP: Heart and Circulatory Physiology - October 1, 2017 Category: Cardiology Authors: Barlow, S. C., Doviak, H., Jacobs, J., Freeburg, L. A., Perreault, P. E., Zellars, K. N., Moreau, K., Villacreses, C. F., Smith, S., Khakoo, A. Y., Lee, T., Spinale, F. G. Tags: RESEARCH ARTICLE Source Type: research