TGF-β1/Smad signaling, MMP-14, and MSC markers in arterial injury: discovery of the molecular basis of restenosis.
In this study, we observed the change in expression and distribution of TGF-β1/Smad signaling pathway proteins, MMP-14, and MSC markers in the process of neointima formation using a rat model for balloon-induced carotid artery injury. We found that the increase in downstream Smad signaling was consistent with the elevation of TGF-β1 levels and MSCs accumulated at the lumen side of neointima. Furthermore, the activation of MMP-14 in the injured artery was preceded by the increase in TGF-β1 levels. Herein, we conclude that MMP-14 induces an elevation in the levels of TGF-β1/Smad signaling proteins in injured arteries, and that MSCs are recruited by TGF-β1/Smad signaling and MMP-14, possibly differentiating into vascular smooth muscle cell (VSMC)-like cells and VSMC via modulation of TGF-β1/Smads signaling and MMP-14.
PMID: 25031710 [PubMed - in process]
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Pang L, Wei C, Duan J, Zou H, Cao W, Qi Y, Jia W, Hu J, Zhao W, Jiang J, Liang W, Li F Tags: Int J Clin Exp Pathol Source Type: research