Bmi-1 regulates epithelial-to-mesenchymal transition to promote migration and invasion of breast cancer cells.
Bmi-1 regulates epithelial-to-mesenchymal transition to promote migration and invasion of breast cancer cells.
Int J Clin Exp Pathol. 2014;7(6):3057-64
Authors: Li H, Song F, Chen X, Li Y, Fan J, Wu X
Abstract
Breast cancer is a highly invasive and metastatic disease. Recent studies report that breast cancer cells that have undergo epithelial-to-mesenchymal transition (EMT) obtain malignant characteristic, however, the molecular mechanism underlying this transition are poorly understood. Here, we found that over-expression associated with the process of breast cancer and that high B-cell-specific moloney murine leukemia virus insertion site 1 (Bmi-1) levels predict shorter survival of breast cancer patients. We demonstrate that Bmi-1 regulates EMT and the migration of breast cancer cells. RNA interference-mediated knockdown Bmi-1 expression restored E-cadherin expression and cell-cell junction formation in breast cancer cells, suppressing cell migration and invasion. In contrast, the over-expression of Bmi-1 decreased the expression of the epithelial mark (E-cadherin) but increased the mesenchymal makers (N-cadherin and vimentin) in breast cancer cells.
PMID: 25031724 [PubMed - in process]
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Li H, Song F, Chen X, Li Y, Fan J, Wu X Tags: Int J Clin Exp Pathol Source Type: research
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