The Human Serum Metabolome of Vitamin B-12 Deficiency and Repletion, and Associations with Neurological Function in Elderly Adults [Genomics, Proteomics, and Metabolomics]

Conclusions: The human serum metabolome in vitamin B-12 deficiency and the changes that occur after supplementation are characterized. Metabolomics revealed connections between vitamin B-12 status and serum metabolic markers of mitochondrial function, myelin integrity, oxidative stress, and peripheral nerve function, including some previously implicated in Alzheimer and Parkinson diseases. This trial was registered at www.controlled-trials.com as ISRCTN02694183.

Source: Journal of Nutrition - October 2, 2017 Category: Nutrition Authors: Brito, A., Grapov, D., Fahrmann, J., Harvey, D., Green, R., Miller, J. W., Fedosov, S. N., Shahab-Ferdows, S., Hampel, D., Pedersen, T. L., Fiehn, O., Newman, J. W., Uauy, R., Allen, L. H. Tags: Research Need: Role of Nutrition in Health Maintenance, Research Need: Role of Nutrition in Medical Management Genomics, Proteomics, and Metabolomics Source Type: research