Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export
The exosome is a key RNA machine that functions in the degradation of unwanted RNAs. Here, we found that significant fractions of precursors and mature forms of mRNAs and long noncoding RNAs are degraded by the nuclear exosome in normal human cells. Exosome-mediated degradation of these RNAs requires its cofactor hMTR4. Significantly, hMTR4 plays a key role in specifically recruiting the exosome to its targets. Furthermore, we provide several lines of evidence indicating that hMTR4 executes this role by directly competing with the mRNA export adaptor ALYREF for associating with ARS2, a component of the cap-binding complex (CBC), and this competition is critical for determining whether an RNA is degraded or exported to the cytoplasm. Together, our results indicate that the competition between hMTR4 and ALYREF determines exosome recruitment and functions in creating balanced nuclear RNA pools for degradation and export.
Authors: Tranchant C Abstract Several environmental toxics are known to induce or to increase occurrence of Parkinson disease while other toxics can provoke basal ganglia necrosis and dopa resistant parkinsonism. After this introduction, the relationship between environment and parkinsonism will be illustrated by 3 short papers: interaction gene-environment, manganese induced Parkinsonism and the Caribbean Food toxins Parkinson plus syndromes. PMID: 31227125 [PubMed - as supplied by publisher]
European hospital pharmacists are demanding that the EU launches an investigation into medicines shortages.
[Nation] Kenya has an adequate supply of two syrups used to treat and prevent HIV/AIDS, the Health ministry has said, noting the stock will last until December 2019.
Infections with herpes simplex virus type (HSV)-1 and HSV-2 are distributed worldwide. Although standard therapies with acyclovir and other synthetic drugs are available, the safety and efficacy of these drugs are limited due to the development of drug resistance and adverse side effects. The literature on essential oils and isolated compounds was reviewed regarding their antiviral activities against HSV-1 and HSV-2. The present overview aims to review experimental data and clinical trials focusing on the antiviral activity of selected essential oils and isolated oil components. HSV was found to be susceptible to many esse...
The largest city in Arkansas is working through fiscal issues inherited by a new mayor and concerns about an out-of-balance budget. Buried in Little Rock’s debits and credits is a potential pool of cash that isn’t what it seems.
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Skip to content ... Minnesota aprueba protecciones en el ámbito de los medicamentos recetados ... Las medidas incluyen el reabastecimiento de medicamentos en caso de emergencia y la divulgación de ...
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