Antimicrobial Activities of Vernonia amygdalina Del and Prunus africana Extracts against Multidrug Resistant Clinical Strains

Background and Objective: Many plant-derived compounds have been used as drugs, either in their original or semi-synthetic forms. Plant derived metabolites can also serve as a lead compounds, which may be used as templates for the development of new drugs. Therefore, the aim of this study was to evaluate the antimicrobial activities of solvent fractions of Vernonia amygdalina shoot apex and Prunus africana bark against multidrug resistant bacterial strains. Materials and Methods: The plant materials were obtained through successive extractions using solvents of different polarity such as petroleum ether, chloroform, acetone and methanol. The antibacterial activities of the fractions were then evaluated by the hole-agar-well diffusion method. The minimum inhibitory concentration of the solvent fraction was determined against the isolated microorganism by agar dilution method. Then, the data were analyzed using Statistical Package for Social Science (SPSS) version 16. p
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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