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Applicability of low-melting-point microcrystalline wax to develop temperature-sensitive formulations

In this study, we focused on microcrystalline wax (MCW) as a low-melting-point substance. We evaluated the drug release behavior of wax matrix (WM) particles using various MCW under various temperature conditions. WM particles containing acetaminophen were prepared using a spray congealing technique. In the dissolution test at 37°C, WM particles containing low-melting-point MCWs whose melting was starting at approx. 40°C (Hi-Mic-1045 or 1070) released the drug initially followed by the release of only a small amount. On the other hand, in the dissolution test at 20 and 25°C for WM particles containing Hi-Mic-1045 and at 20, 25, and 30°C for that containing Hi-Mic-1070, both WM particles showed faster drug release than at 37°C. The characteristic drug release suppression of WM particles containing low-melting-point MCWs at 37°C was thought attributable to MCW melting, as evidenced by differential scanning calorimetry analysis and powder X-ray diffraction analysis. Taken together, low-melting-point MCWs may be applicable to develop implantable temperature-sensitive formulations that drug release is accelerated by cooling at administered site. Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
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Source: Physical Medicine and Rehabilitation Clinics of North America - Category: Rehabilitation Authors: Source Type: research
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Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
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Source: Journal of Forensic Radiology and Imaging - Category: Radiology Source Type: research
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Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
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Source: The Journal of Supercritical Fluids - Category: Chemistry Source Type: research
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Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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