Performance comparison between crystalline and co-amorphous salts of indomethacin-lysine

Publication date: 25 November 2017 Source:International Journal of Pharmaceutics, Volume 533, Issue 1 Author(s): Georgia Kasten, Khatera Nouri, Holger Grohganz, Thomas Rades, Korbinian Löbmann The introduction of a highly water soluble amino acid as co-amorphous co-former has previously been shown to significantly improve the dissolution rate of poorly water soluble drugs. In this work, dry ball milling (DBM) and liquid assisted grinding (LAG) were used to prepare different physical forms of salts of indomethacin (IND) with the amino acid lysine (LYS), allowing the direct comparison of their solid-state properties to their in vitro performance. X-ray powder diffraction and Fourier-transformed infrared spectroscopy showed that DBM experiments led to the formation of a fully co-amorphous salt, while LAG resulted in a crystalline salt. Differential scanning calorimetry showed that the samples prepared by DBM had a single glass transition temperature (Tg ) of approx. 100°C for the co-amorphous salt, while a new melting point (223°C) was obtained for the crystalline salt prepared by LAG. Intrinsic dissolution and powder dissolution studies demonstrated an increased dissolution rate of the drug in the co-amorphous salt compared to pure amorphous IND and also the crystalline drug-LYS salt. Furthermore, the co-amorphous IND-LYS salt presented long term physical stability in dry conditions at 25°C and 40°C. Overall, it has been shown that the co-amorphous form of...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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In this study, we describe a nanostructured ZnO adsorbent, which displays remarkable efficiency toward the removal of widely used azo dyes, methyl orange (MO) and amaranth (AM), from aqueous systems. The ZnO nanoparticles (ZnO-NPs) were prepared by simple co-precipitation method, and the structural morphology of the as-prepared NPs was revealed by X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform IR (FTIR) and Brunauer–Emmett–Teller (BET). After complementary characterization, as-prepared ZnO-NPs were further used as adsorbent for the removal of toxic azo dyes (MO and AM) from water...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
Authors: Ryu S, Chang Y, Kim YS, Kim HJ Abstract OBJECTIVES: We aimed to examine the relationship between sitting time and the development of ultrasonography-diagnosed gallstone disease (GSD) in young and middle-aged Korean men and women. MATERIAL AND METHODS: We conducted a cohort study of 147,237 participants without GSD at baseline who underwent a health checkup examination between 2011 and 2015 and were followed annually or biennially until December 2016. Sitting time and physical activity were measured using the validated Korean version of the international physical activity questionnaire short form. GSD w...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Publication date: 1 November 2018Source: Carbohydrate Polymers, Volume 199Author(s): Rahmi, Lelifajri, Rizki NurfatimahAbstractPreparation and characterization of polyethylene glycol diglycidyl ether (PEDGE) crosslinked chitosan/activated carbon composite film have been conducted. PEDGE was used as crosslinking agent and activated carbon as a filler on composite film preparation. The composite films were produced with several ratios of chitosan/PEDGE/activated carbon. Tensile test, Fourier Transform Infrared (FTIR), X-Ray Diffraction (XRD) and Scanning electron Microscope (SEM) were used to study the structure and properti...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 21 July 2018Source: International Journal of PsychophysiologyAuthor(s): Erin D. Bigler, Chris Finuf, Tracy J. Abildskov, Naomi J. Goodrich-Hunsaker, Jo Ann Petrie, Dawn-Marie Wood, John R. Hesselink, Elisabeth A. Wilde, Jeffrey E. MaxAbstractThis investigation explored whether differences in cortical thickness could be detected in children who sustained a mild traumatic brain injury (mTBI) compared to those with orthopedic injury (OI) and whether cortical thickness related parental reporting of symptoms. To achieve this objective, FreeSurfer®-based cortical thickness measures were obt...
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 21 July 2018Source: NeuropsychologiaAuthor(s): Nancy Stirnimann, Karim N'Diaye, Florence Le Jeune, Jean-François Houvenaghel, Gabriel Robert, Sophie Drapier, Dominique Drapier, Didier Grandjean, Marc Vérin, Julie PéronAbstractThe possible hemispheric specialization of the basal ganglia during emotional prosody (i.e., vocal emotion) processing has still to be elucidated. Coupled with affective measures and neuroimaging, Parkinson's disease offers a unique opportunity to study this question, on account of its characteristically asymmetric striatal dysfunction, which tra...
Source: Neuropsychologia - Category: Neurology Source Type: research
ConclusionsThese results elucidate regional brain volume differences associated with preterm birth and perinatal factors at a more detailed parcellated level than previously reported, and contribute to understanding of the complex array of correlates of preterm birth.
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: August 2018Source: Journal of Environmental Chemical Engineering, Volume 6, Issue 4Author(s): Anwar Iqbal, S. Sabar, M.K. Mun-Yee, M.N. Nur Asshifa, A.R.M. Yahya, Farook AdamAbstractA novel biosorbent (RHA-PA) for the adsorption of methylene blue (MB) was developed by immobilizing deactivated Pseudomonas aeruginosa USM-AR2 (PA) cells on mesoporous rice husk ash silica (RHA-SiO2). The RHA-SiO2 was synthesized via sol-gel method with fructose as a water-soluble template. The highest Brunauer-Emmett-Teller (BET) surface area (601 m2 g−1) determined from N2 adsorption-desorption analysis w...
Source: Journal of Environmental Chemical Engineering - Category: Chemistry Source Type: research
Publication date: Available online 20 July 2018Source: Journal of Electroanalytical ChemistryAuthor(s): Xiaoyu Zhao, Jianhua Ding, Wenlong Bai, Yanfei Wang, Yujia Yan, Yan Cheng, Juankun ZhangAbstractA PEDOT:PSS/AuNPs/CA modified screen-printed carbon based disposable electrochemical sensor for sensitive and selective determination of carmine was studied. Enhanced electrode conductivity was achieved via a 3-step process: (i) construction of a conductive polymer (PEDOT: PSS) on a disposable screen-printed carbon electrode (SPCE) (ii) electropolymerization with gold nanoparticles (AuNPs) and (iii) modification with positivel...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
Publication date: 30 October 2018Source: Journal of Alloys and Compounds, Volume 767Author(s): Hang Zhang, Yujun Liang, Yingli Zhu, Shiqi Liu, Kai Li, Jian Yang, Wen LeiAbstractNovel single-phased and emission-tunable layered Bi4Ti3O12:Pr3+ nanosheets have been successfully synthesized via molten salt method. The as-prepared samples were characterized by X-ray diffraction and scanning electron microscopy to investigate their crystalline phases and morphologies. Furthermore, we explored the photoluminescence properties of the Bi4Ti3O12:Pr3+ phosphors, while the cross-relaxation processes between 1D2, 3P0 emitting states and...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
Publication date: 30 October 2018Source: Journal of Alloys and Compounds, Volume 767Author(s): Rafaela S. Andre, Jessica C. Pereira, Luiza A. Mercante, Danilo Locilento, Luiz H.C. Mattoso, Daniel S. CorreaAbstractNanostructured metal oxide semiconductors (MOS) based chemoresistive sensors play an important role in designing handheld, portable and cost-effective sensing systems for the detection of various target analytes. Herein, one-dimensional ZnO-Co3O4 heterostructure nanofibers (NFZCo) were successfully fabricated via electrospinning technique followed by a high-temperature treatment. The heterostructured nanofibers we...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
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