Arginine infusion in septic shock patients increases nitric oxide production without hemodynamic instability

In conclusion, a4-fold increase of plasma arginine with intravenous arginine infusion in sepsis stimulates de novo arginine and NO production and reduces whole body protein breakdown. These potential beneficial metabolic effects occurred without negative alterations in hemodynamic parameters, although improvement of regional perfusion could not be demonstrated in the eight patients with septic shock that were studied.

http://www.clinsci.org/cs/imps/refer.htm?MSID=CS20140343

Source: Clinical Science - July 18, 2014 Category: Biomedical Science Authors: Y C Luiking, M Poeze, N EP Deutz Source Type: research