Allopurinol Augmentation in Acute Mania: A Meta-Analysis of Placebo-Controlled Trials

Allopurinol is a xanthine oxidase inhibitor commonly used in the treatment of gout. Recent studies have also shown its promise as an adjunctive treatment for manic episodes in bipolar 1 disorder, possibly through mechanisms involving the purinergic pathway. However, its efficacy across studies has been inconsistent, so we conducted a meta-analysis of the published controlled studies with the goal of determining the efficacy profile of allopurinol as an adjunctive treatment for mania in bipolar disorder.

Source: Journal of Affective Disorders - September 30, 2017 Category: Neurology Authors: Alexander T. Chen, Theodore Malmstrom, Henry A. Nasrallah Tags: Review article Source Type: research