Immune cell's role in intestinal movement may lead to better understanding of IBS

(Penn State) Learning the role of immune-system cells in healthy digestive tracts and how they interact with neighboring nerve cells may lead to new treatments for irritable bowel syndrome.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Publication date: Available online 9 November 2019Source: Clinica Chimica ActaAuthor(s): Kamyar Khoshnevisan, Elham Honarvarfard, Farzad Torabi, Hassan Maleki, Hadi Baharifar, Farnoush Faridbod, Bagher Larijani, Mohammad Reza KhorramizadehAbstractSerotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter which plays a significant role in various functions in the body, such as appetite, emotions, and autonomic functions. It is well known that biomarker 5-HT levels can be correlated to several diseases and disorders such as depression, anxiety, irritable bowel, and sleep trouble. Among various methods for detecti...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Authors: Wilder-Smith CH, Drewes AM, Materna A, Olesen SS Abstract Objectives: Mast cell involvement is evident in functional gastrointestinal disorders (FGID). FGID and mast cell activation syndrome (MCAS) are associated with multi-organ symptoms. An overlap has not been assessed.Methods: MCAS symptoms were determined by questionnaires in 2083 FGID patients.Results: The median number of MCAS symptoms ([IQR] (range 0-16)) was 6 [4-8] in all FGID, and in functional dyspepsia (FD) patients, 7 [5-9] in overlapping irritable bowel syndrome and FD (IBS+FD), 5 [3-8] in IBS and 5 [3-6] in non-IBS/non-FD (p 
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
AbstractIrritable bowel syndrome (IBS) is a functional bowel disorder characterized by abdominal pain and alterations in stool form and/or frequency, leading to reduced quality of life. Pharmacologic agents currently approved by the US Food and Drug Administration for treatment of IBS with diarrhea (IBS-D) in adults are the nonsystemic antibiotic rifaximin, the mixed µ- and κ-opioid receptor agonist/δ-opioid antagonist eluxadoline, and the selective serotonin 5-HT3 antagonist alosetron (the last of which is indicated only in women with severe IBS-D refractory to conventional therapy). Both eluxadoline and...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
AbstractPurpose of ReviewGluten is a commonly ingested polymeric protein found in wheat, barley, and rye that has gained recent notoriety because of its relationship to disease and health. Avoidance of gluten is appropriate in patients with a diagnosed gluten –related disorder and may have treatment implications in other diseases of the digestive tract. This review highlights current knowledge of gluten related disorders and the use of a gluten-free diet in gastrointestinal disease management.Recent FindingsGluten-free diets should be used in patients with a diagnosed gluten –related disorder including celiac d...
Source: Current Treatment Options in Gastroenterology - Category: Gastroenterology Source Type: research
ConclusionsLow or very low certainty evidence indicated that there was no difference between CGEC and WCM in the treatment of IBS-D. The combination of CGEC and WCM has a better therapeutic effect than WCM alone in the treatment of IBS-D. Future large sample, multi-center and high-quality RCTs should be rigorously designed and implemented to evaluate the clinical effects and safety of CGEC for IBS-D.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Irritable bowel syndrome (IBS) is characterized by abdominal pain, bloating, and erratic bowel habits. A diet low in fermentable oligo-, di-, mono-saccharides and polyols (FODMAPs) can reduce symptoms of IBS, possibly by reducing microbial fermentation products. We investigated whether ingestion of FODMAPs can induce IBS-like visceral hypersensitivity mediated by fermentation products of intestinal microbes in mice.
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
PMID: 31676061 [PubMed - in process]
Source: The Surgical Clinics of North America - Category: Surgery Authors: Tags: Surg Clin North Am Source Type: research
AbstractObjectiveTo observe the clinical efficacy of acupuncture treatment for depressive symptom in diarrhea-predominant irritable bowel syndrome (IBS-D).MethodsA total of 70 patients with IBS-D accompanied by depressive symptom were randomized into a control group and an observation group, with 35 cases in each group. The control group was treated with oral intake of pinaverium bromide tablets, and the observation group was treated with regulating liver and spleen acupuncture treatment. The two groups were treated for 4 weeks. The scores of IBS symptom severity scale (IBS-SSS) and self-rating depression scale (SDS) were ...
Source: Journal of Acupuncture and Tuina Science - Category: Complementary Medicine Source Type: research
This JAMA Insights Clinical Update summarizes treatment options for individuals with chronic idiopathic constipation, irritable bowel syndrome with constipation, and opioid-induced constipation and summarizes recent guidelines that conclude that traditional laxatives should be used as first-line agents for the management of constipation because of low cost and high benefit.
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research
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