Receptor Structure-Based Discovery of Non-metabolite Agonists for the Succinate Receptor GPR91

Conclusions These novel, synthetic non-metabolite GPR91 agonists will be valuable both as pharmacological tools to delineate the GPR91-mediated functions of succinate and as leads for the development of GPR91-targeted drugs to potentially treat low grade metabolic inflammation and diabetic complications such as retinopathy and nephropathy.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research