Clinical biochemistry profile of biventricular heart failure in a mixed-breed bitch

AbstractA six-year old mixed-breed bitch was presented for chronic ascites. A diagnostic work-up was crafted to ascertain the cause of fluid accumulation in the peritoneal cavity. Clinical biochemistry tests for status of the liver and kidneys were performed. Elevations in absolute concentrations of the liver enzymes aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were useful in evaluation of hepatocellular damage associated with right-sided heart failure. Normal levels of serum albumin and bilirubin, however, underscored the preserved functional capacity of the liver in spite of hepatocellular damage. Elevation of blood urea nitrogen, but not creatinine, was significant in appraisal of low cardiac output chronic renal failure resulting from left-sided heart failure. Increase in blood urea nitrogen was a valuable prognostic indicator of subsequent death resulting from biventricular heart failure, in contrast to serum bilirubin or albumin concentrations. Clinical biochemical profiles for liver and kidney functions in heart failure patients allow for estimation of the extent of hepatic and renal complications. Renal dysfunction carries a grave prognosis.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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DISCUSSION: ED utilization after outpatient hand surgery is low, with postoperative pain being the most common cause of an ED visit at all time points. Nearly 98% of patients presenting to the ED for postoperative pain are subsequently discharged home. LEVEL OF EVIDENCE: Level III, Retrospective Cohort. PMID: 31714419 [PubMed - as supplied by publisher]
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health. Towards a Rigorous Definition of Cellular Senescence https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/ The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the productio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 9 November 2019Source: The Annals of Thoracic SurgeryAuthor(s): Zaid M. Abdelsattar, Elizabeth Habermann, Bijan J. Borah, James P. Moriarty, Ricardo L. Rojas, Shanda H. BlackmonAbstractBACKGROUNDData on failure to rescue (FTR) after esophagectomy are sparse. We sought to better understand the patient factors associated with FTR, and assessed whether FTR is associated with hospital volume.METHODSWe identified all patients undergoing esophagectomy between 2010 and 2014 from the AHRQ Nationwide Readmission Database. We defined FTR as mortality after a major complication. Multiple logistic re...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: November–December 2019Source: Heart &Lung, Volume 48, Issue 6Author(s): Barak Zafrir, Shemy Carasso, Sorel Goland, Liaz Zilberman, Robert Klempfner, Nir Shlomo, Evgeny Radzishevsky, Tal Hasin, Avraham Shotan, Alicia Vazan, Jean Marc Weinstein, Wadi Kinany, Robert Dragu, Elad Maor, Liza Grosman-Rimon, Offer AmirAbstractBackgroundThe most common cause of pulmonary hypertension (PH) in developed countries is left heart disease (LHD, group 2 PH). The development of PH in heart failure (HF) patients is indicative of worse outcomes.ObjectiveThe aim of this study was to evaluate the long term outcomes ...
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
This study is aimed to evaluate the management of acute kidney injury (AKI) in our inner city, American hospital. We intended to ascertain whether or not there is prompt recognition of AKI in cirrhosis according to International Club of Ascites and acute kidney injury network criteria as well how effective we are at distinguishing among different causes of AKI. We aimed to calculated the mortality of hepatorenal syndrome (HRS) in our hospital, and to evaluate the adequacy of the established treatment of AKI at each stage of its algorithm. Patients and methods ICD diagnostic codes were used to identify patients with live...
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
Abstract BACKGROUND: Data on failure to rescue (FTR) after esophagectomy are sparse. We sought to better understand the patient factors associated with FTR, and assessed whether FTR is associated with hospital volume. METHODS: We identified all patients undergoing esophagectomy between 2010 and 2014 from the AHRQ Nationwide Readmission Database. We defined FTR as mortality after a major complication. Multiple logistic regression was used to identify patient factors and hospital-volume associations with FTR. RESULTS: Of 26,820 patients undergoing an esophagectomy, 7,130 (26.6%) experienced a major complic...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
CONCLUSIONS: In BIOSTAT-CHF, patients with HF of an ischemic etiology, and those with worsening HF precipitated by renal failure (irrespective of the underlying HF etiology), had the highest rates of death and HF hospitalization, but still benefited equally from treatment up-titration. PMID: 31708361 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Eur J Intern Med Source Type: research
In this study, we developed gene therapies based on 3 longevity associated genes: fibroblast growth factor 21 (FGF21), αKlotho, soluble form of mouse transforming growth factor-β receptor 2 (sTGFβR2). The gene therapies were delivered using adeno-associated viruses, and we explored their ability to mitigate 4 age-related diseases: obesity, type II diabetes, heart failure, and renal failure. Individually and combinatorially, we applied these therapies to disease-specific mouse models and found that this set of diverse pathologies could be effectively treated and in some cases, even reversed with a sin...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Purpose of review Evaluating patient outcomes is essential in a healthcare environment focused on quality. Mortality after surgery has been considered a useful quality metric. More important than mortality rate, failure to rescue (FTR) has emerged as a metric that is important and may be improveable. The purpose of this review is to define FTR, describe patient and hospital level factors that lead to FTR, and highlight possible solutions to this problem. Recent findings FTR is defined as a death following a complication. Depending on the patient population, FTR rates vary from less than 1% to over 40%. Numerous patien...
Source: Current Opinion in Critical Care - Category: Nursing Tags: THE SURGICAL PATIENT: Edited by Terence O’Keeffe Source Type: research
AbstractBackgroundPatients with rheumatoid arthritis (RA) are at a high risk for life-threatening conditions requiring admission to the intensive care unit (ICU), but the data regarding the outcomes of these patients is limited. The present study investigated the clinical characteristics and outcomes of RA patients admitted to an ICU.MethodsThis retrospective cohort study included RA patients admitted to the general ICU of the Sheba Medical Center during 2002 –2018. The main outcome was 30-day mortality. Using Student’st test,χ2, and multivariable analyses, we compared the demographic, clinical, and laborat...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
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