KLK5 induces shedding of DPP4 from circulatory Th17 cells in Type 2 Diabetes

Conclusions Our study provides mechanistic insights into the molecular interaction between KLK5 and DPP4 as well as CD4+ T cell derived KLK5 mediated enzymatic cleavage of DPP4 from cell surface. Thus, our study uncovers a hitherto unknown cellular source and mechanism behind enhanced plasma DPP4 activity in T2DM. Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research