LPS-induced cortical kynurenic acid and neurogranin-NFAT signaling is associated with deficits in stimulus processing during Pavlovian conditioning

This study indicates that systemic dual-lipopolysaccharide (LPS) injections increases KYNA in the medial prefrontal cortex (mPFC), which is accompanied with increased phosphorylation of nuclear factor kappa chain of activated B cells (NF κB) and activation of the nuclear factor of activated T- cells (NFAT).

http://www.jni-journal.com/article/S0165-5728(16)30465-9/fulltext?rss=yes

Source: Journal of Neuroimmunology - September 28, 2017 Category: Allergy & Immunology Authors: A. Oliveros, K. Wininger, J. Sens, M.K. Larsson, X.C. Liu, S. Choi, A. Faka, L. Schwieler, G. Engberg, S. Erhardt, D.S. Choi Source Type: research