Axovant ’s Phase III trial of Alzheimer's disease drug fails to meet primary endpoints

Axovant Sciences has reported negative top-line results from its Phase III MINDSET clinical trial of intepirdine conducted to treat mild-to-moderate Alzheimer's disease (AD).
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news

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CONCLUSIONS: These findings indicated that applying the population-specific brain atlas to neuroimaging studies may achieve higher accuracy in activation detection. This may have implications to the imaging study of neurodegenerative diseases. PMID: 30024411 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
This study aimed to evaluate the effects of sevoflurane on working memory of rats and to characterize functional connectivity between excitatory neurons in the prefrontal cortex (PFC) during working memory performance.Methods18-month-old and 3-month-old male SD rats were implanted with a multielectrode array in the PFC. After recovery from the surgery, the aged and adult rats were divided into sevoflurane group and control group, respectively. Rats in sevoflurane group were exposed to 1 minimum alveolar concentration (MAC) or 1.5 MAC sevoflurane for two hours. At day1, 3, and 7 after exposure, the effects of sevoflurane an...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
MULTI-TASK SPARSE SCREENING FOR PREDICTING FUTURE CLINICAL SCORES USING LONGITUDINAL CORTICAL THICKNESS MEASURES. Proc IEEE Int Symp Biomed Imaging. 2018 Apr;2018:1406-1410 Authors: Zhang J, Tu Y, Li Q, Caselli RJ, Thompson PM, Ye J, Wang Y Abstract Cortical thickness estimation performed in-vivo via magnetic resonance imaging (MRI) is an effective measure of brain atrophy in preclinical individuals at high risk for Alzheimer's disease (AD). However, the high dimensionality of individual cortical thickness data coupled with small population samples make it challenging to perform cortical thickness feat...
Source: Proceedings - International Symposium on Biomedical Imaging - Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research
Publication date: Available online 20 July 2018Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Yu Zhang, Yudan Zhao, Zhuoyi Wang, Hao Gong, Liang Ma, Dongsheng Sun, Chen Yang, Yang Li, Biao Cheng, Robert B. Petersen, Fengchao Jiang, Gongping Liu, Kun HuangAbstractProtein misfolding and aggregation are associated with amyloidosis. The toxic aggregation of amyloid-β 1–42 (Aβ42) may disrupt cell membranes and lead to cell death and is thus regarded as a contributing factor in Alzheimer's disease (AD). 1,4-naphthoquinone (NQ) has been shown to exhibit strong anti-aggregation effects on ...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
In this study, by crossing hAPP (human amyloid prec ursor protein)-J20 mice with a line of GFAP-TK mice, we found that astrocytes were activated specifically at an early stage of AD before the occurrence of amyloid plaques, while microglia were not affected by this crossing. Activation of astrocytes at the age of 3–5 months did not affect the prot eolytic processing of hAPP and amyloid plaque loads in the brains of hAPP-J20 mice. Our data suggest that early activation of astrocytes does not affect the deposition of amyloid β in an animal model of AD.
Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research
AbstractData Mining in medicine is an emerging field of great importance to provide a prognosis and deeper understanding of disease classification, specifically in Mental Health areas. The main objective of this paper is to present a review of the existing research works in the literature, referring to the techniques and algorithms of Data Mining in Mental Health, specifically in the most prevalent diseases such as: Dementia, Alzheimer, Schizophrenia and Depression. Academic databases that were used to perform the searches are Google Scholar, IEEE Xplore, PubMed, Science Direct, Scopus and Web of Science, taking into accou...
Source: Journal of Medical Systems - Category: Information Technology Source Type: research
Publication date: Available online 20 July 2018Source: Alzheimer's &DementiaAuthor(s): Juan Antonio García-León, Alfredo Cabrera-Socorro, Kristel Eggermont, Ann Swijsen, Joke Terryn, Raheem Fazal, FatemehArefeh Nami, Laura Ordovás, Ana Quiles, Frederic Lluis, Lutgarde Serneels, Keimpe Wierda, Annerieke Sierksma, Mohamed Kreir, Francisco Pestana, Philip Van Damme, Bart De Strooper, Lieven Thorrez, Andreas Ebneth, Catherine M. VerfaillieAbstractTauopathies are neurodegenerative diseases characterized by TAU protein–related pathology, including frontotemporal dementia and Alzheimer's disease amo...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Yann Fichou, Michael Vigers, Andrew K. Goring, Neil A. Eschmann, Songi Han To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
See something of interest? Please share our postings with colleagues in your institutions! Spotlight The MAReport: Check out the Spring 2018 issue of the MAReport newsletter! This quarter, Academic Coordinator Elaina Vitale talked about using evidence-based resources to improve citations on Wikipedia, and her experience with NNLM’s first virtual Wikipedia Edit-a-thon. National Network of Libraries of Medicine News Dementia and Alzheimer’s Services @ Your Library – Midwest Matters, from GMR The next round of PubMed for Librarians begins August 29. Register for any (or all) of the PML classes to learn ...
Source: NN/LM Middle Atlantic Region Blog - Category: Databases & Libraries Authors: Tags: Weekly Postings Source Type: news
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
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