The origin of 7alpha-hydroxy-dehydroepiandrosterone and its physiological role: a history of discoveries.

The origin of 7alpha-hydroxy-dehydroepiandrosterone and its physiological role: a history of discoveries. Physiol Res. 2017 Sep 26;66(Supplementum 3):S285-S294 Authors: Stárka L Abstract Nearly 60 years has elapsed since the first isolation and identification of 7alpha-hydroxy-dehydroepiandrosterone, and in that time much information has been gained on its occurrence, metabolism, ontogeny, immunomodulatory activity, cell proliferation, cortisol control in local tissues and neuroactivity. Additional knowledge about this steroid may elucidate its role in obesity, neurodegenerative disturbances such as Alzheimer's disease, or psychiatric disorders such as schizophrenia or depression. This review aims to provide a comprehensive summary of the available literature on 7alpha-hydroxy-dehydroepiandrosterone. PMID: 28948812 [PubMed - in process]
Source: Physiological Research - Category: Physiology Authors: Tags: Physiol Res Source Type: research