Heart drug niacin may pose serious health risks
Research has found a troubling rise in deaths among people who use popular drug to manage cholesterol
For most people at risk of heart attack and stroke, using statins to lower cholesterol brings more benefits than risks, say the American Heart Association.
ConclusionThe DCCM-based intervention leads to improved glycemic control parameters indicative of diabetes control. Clinically significant change was observed in treatment group only. Integrative diabetes care appears especially well suited for fragmented healthcare systems with limited resources.
Publication date: Available online 10 December 2018Source: SteroidsAuthor(s): Vinay Narwal, Ritu Deswal, Bhawna Batra, Vijay Kalra, Ritu Hooda, Minakshi Sharma, J.S. RanaAbstractCholesterol is the most important sterol synthesized by most of the human cells majorly in the liver. It is a necessary constituent of cell membranes, it acts as a precursor for the synthesis of steroid hormones, vitamin D, and bile acids. Cholesterol is transported in plasma primarily in the form of low-density lipoproteins (LDL), the principal route for its removal from tissues to the liver is in high-density lipoproteins (HDL), followed by excre...
This open access commentary notes the evidence to suggest that therapies based on raised levels of pyrophosphate in blood vessel walls to reduce age-related calcification. The mineralization of blood vessel walls through deposition of calcium, calcification, is one of the mechanisms that contributes to vascular stiffness with age. It impairs the ability of blood vessels to contract and relax as they should. This is a serious issue, as it breaks the feedback mechanisms that control blood pressure, leading to hypertension, vascular disease, and heart failure as heart muscle grows and weakens. From my point of view, th...
J. Murry Isoprenoids (IsoP) are an important class of molecules involved in many different cellular processes including cholesterol synthesis. We have developed a sensitive and specific LC-MS/MS method for the quantitation of three key IsoPs in bio-matrices, geranyl pyrophosphate (GPP), farnesyl pyrophosphate (FPP), and geranylgeranyl pyrophosphate (GGPP). LC-MS/MS analysis was performed using a Nexera UPLC System connected to a LCMS-8060 (Shimadzu Scientific Instruments, Columbia, MD) with a dual ion source. The electrospray ionization source was operated in the negative MRM mode. The chromatographic separation and d...
The benefits of statins are clear, and side effects from the cholesterol-fighting drugs are rare, according to a new analysis of decades of scientific research.
Research published last week sparked uproar: Swiss scientists found the benefits only outweigh the risks for people with a very high heart attack risk. But the AHA says: take the study with a pinch of salt.
(Reuters Health) - - The benefits of statins in reducing the odds of heart attacks and strokes far outweigh any risks of side effects, according to a scientific statement released by the American Heart Association.
Condition: Rheumatoid Arthritis Interventions: Drug: Angiotensin receptor blockers; Drug: Statins Sponsor: Sherief Abd-Elsalam Recruiting
Condition: Healthy Elderly Individuals With High LDL-cholesterol or Risk of Cardiovascular Disease Interventions: Drug: Low intensity statin; Drug: Moderate intensity statin Sponsor: Yonsei University Not yet recruiting