Azanza garckeana Fruit Tree: Phytochemistry, Pharmacology, Nutritional and Primary Healthcare Applications as Herbal Medicine: A Review
This study was aimed at reviewing the nutritional value, the phytochemical compounds, ethnomedicinal uses and validated pharmacological properties of A. garckeana. The extensive literature survey revealed that ripe fruit carpels of A. garckeana are edible and widely used as food additives throughout the distributional range of the species. Azanza garckeana is also traditionally used to treat or manage at least 22 human diseases and ailments. The species is used as herbal medicine for diseases and ailments such as chest pains, cough, infertility, liver problems, menstruation problems and sexually transmitted infections. Multiple classes of compounds including alkaloids, amino acids, ascorbic acid, carotenoids, cyanogenic glucosides, flavonoids, lipids, phenols, saponins and tannins have been isolated from A. garckeana. Pharmacological studies on A. garckeana indicate that the species has a wide range of pharmacological activities such as antibacterial, antifungal, antihyperglycemic, antimalarial, antioxidant and iron absorption. Azanza garckeana is worth to be subjected to detailed scientific investigations for elucidating its chemical, nutritional and toxicological properties. Such detailed research should also include experimental animal studies, randomized clinical trials and target-organ toxicity studies involving A. garckeana and its derivatives.
This study aims to verify the morphokinetic criteria to discriminate good morphological blastocyst (group I) from poor morphological blastocyst (group II) by using Primo vision® (Vitrolife, Sweden). Material and Method: The prospective study was performed in infertile couples treated with assisted reproductive technology at Thammasat Fertility Center, Thailand, in 2015. The morphokinetic study was compared between the two groups by t-test and Mann-Whitney U test with p
Authors: Mancini F, Vescio F, Mochi S, Accardi L, di Bonito P, Ciervo A Abstract Chlamydia trachomatis (Ct) and human papillomavirus (HPV) are the most common sexually transmitted pathogens. Whereas it is well known that infection with oncogenic HPV genotypes increases the risk of cervical cancer (CC), the implication of Ct in the pathogenesis of CC is still controversial. Hence, to investigate the possible implication of Ct infection alone, or with concomitant HPV infection, in the severity of cervical lesions, we conducted a study in 164 Caucasian HIV-negative women with abnormal Pap. Genomic HPV and Ct DNA were ...
[Malawi News Agency] Lilongwe -In its efforts of taking HIV and Aids testing as part of the fight against the scourge, the Malawi Government through the Ministry of Health intends to roll out self-testing facility for HIV in order to enable many people know their status and seek relevant medical attention.
My next blog post will be entitled " The Lie of Precision Medicine "— sarcastic_f (@sarcastic_f)June 23, 2018This post will be my own personalized rant about the false promises of personalized medicine. It will not be about neurological or psychiatric diseases, the typical topics for this blog. It will be about oncology, for very personal reasons: misery, frustration, and grief. After seven months of research on immunotherapy clinical trials, I couldn't find a single [acceptable] one1 in either Canada or the US that would enroll my partner with stage 4 cancer. For arbitrary reasons, for financial reaso...
CONCLUSION: First line management of infertility once a diagnosis of PCOS is made should include weight loss and exercise with goals to below class 2 obesity (BMI
In this study we report on the investigation of complete infertility in a 5-year-old Thoroughbred stallion. The stallion was considered infertile after performing 72 covers and achieving 0 pregnancies over one breeding season. Although initial semen assessment (sperm concentration, motility, longevity and morphology) revealed below average parameters, these were not sufficient to explain complete infertility under a managed system. The stallion displayed normal libido, breeding behavior and ejaculation, and semen contained viable, progressively motile spermatozoa (number of total progressively motile sperm per ejaculate ra...
Seminal vesiculitis is one of the causes of pyospermia affecting the fertility of stallions. To date, recommended treatments have variable results and reoccurrence is a common sequela. The development of management tools for stallions affected is warranted. Thus, the objective of this study was to evaluate fractionated semen collection as a method to rescue fertility of stallions diagnosed with seminal vesiculitis. The study was performed from April of 2014 to October of 2017 with six light-breed stallions with a history of infertility and pyospermia.
The imbalance between reactive oxygen species (ROS) generation and antioxidant defensive mechanisms results in excessive ROS levels that promote sperm DNA fragmentation, mitochondrial dysfunction and membrane lipid peroxidation, which are associated with infertility. Curcumin (CUR, Curcuma longa) is a natural phytochemical compound of turmeric that exhibits antioxidant properties. CUR can have beneficial effect on sperm motility by increasing antioxidant mechanisms and controlling lipid peroxidation and nitric oxide production.
Low levels of intracellular reactive oxygen species (ROS) are essential for normal spermatozoal function and are produced by sperm mitochondria as a byproduct of metabolism, but in excess, ROS can cause catastrophic cellular damage and has been correlated with infertility, poor sperm motility and abnormal morphologies in humans (Aziz et. al. Fertility and Sterility. 2004; 2: 349-354). Stallion sperm fuel motility predominantly by oxidative phosphorylation-produced ATP, requiring high basal rates of mitochondrial function.
While it is well established that mammalian male fertility has a genetic component, genomics tools for evaluating fertility in stallions are limited. The Y chromosome is enriched with genes important for spermatogenesis and sperm functions as evidenced by human and mouse studies showing causative links between Y chromosome rearrangements, mutations, copy number variants (CNVs) and various male infertility phenotypes; hence, Y chromosome studies were initiated in the horse. We recently produced a 9.5 Mb annotated reference sequence for the male specific region of the horse Y (MSY).