Sex- and Dose-Specific Effects of Maternal Bisphenol A Exposure on Pancreatic Islets of First- and Second-Generation Adult Mice Offspring

Conclusion: These findings demonstrate that maternal BPA exposure has dose- and sex-specific effects on pancreatic islets of adult F1 and F2 mice offspring. The transmission of these changes across multiple generations may involve either mitochondrial dysfunction and/or epigenetic modifications. https://doi.org/10.1289/EHP1674 Received: 25 January 2017 Revised: 26 July 2017 Accepted: 26 July 2017 Published: 27 September 2017 Please address correspondence to R.A. Simmons, Center for Research on Reproduction and Women’s Health, Perelman School of Medicine, University of Pennsylvania, 1308 BRB II/III, 421 Curie Blvd., Philadelphia, PA 19104 USA. Telephone: (215) 662-3269. Email: rsimmons@mail.med.upenn.edu; or M.S. Bartolomei, Center for Research on Reproduction and Women’s Health, Perelman School of Medicine, University of Pennsylvania, 1308 BRB II/III, 421 Curie Blvd., Philadelphia, PA 19104 USA. Telephone: (215) 898-9063. Email: bartolom@mail.med.upenn.edu Supplemental Material is available online (https://doi.org/10.1289/EHP1674). The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@ni...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research