Sex- and Dose-Specific Effects of Maternal Bisphenol A Exposure on Pancreatic Islets of First- and Second-Generation Adult Mice Offspring
Conclusion:
These findings demonstrate that maternal BPA exposure has dose- and sex-specific effects on pancreatic islets of adult F1 and F2 mice offspring. The transmission of these changes across multiple generations may involve either mitochondrial dysfunction and/or epigenetic modifications. https://doi.org/10.1289/EHP1674
Received: 25 January 2017
Revised: 26 July 2017
Accepted: 26 July 2017
Published: 27 September 2017
Please address correspondence to R.A. Simmons, Center for Research on Reproduction and Women’s Health, Perelman School of Medicine, University of Pennsylvania, 1308 BRB II/III, 421 Curie Blvd., Philadelphia, PA 19104 USA. Telephone: (215) 662-3269. Email: rsimmons@mail.med.upenn.edu; or M.S. Bartolomei, Center for Research on Reproduction and Women’s Health, Perelman School of Medicine, University of Pennsylvania, 1308 BRB II/III, 421 Curie Blvd., Philadelphia, PA 19104 USA. Telephone: (215) 898-9063. Email: bartolom@mail.med.upenn.edu
Supplemental Material is available online (https://doi.org/10.1289/EHP1674).
The authors declare they have no actual or potential competing financial interests.
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Source: EHP Research - Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
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