Long-Term Air Pollution Exposure and Amyotrophic Lateral Sclerosis in Netherlands: A Population-based Case –control Study

Author Affiliations open 1Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands 2Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands 3Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands 4Department of Neurology, Amsterdam Medical Center, University of Amsterdam, Amsterdam, Netherlands 5Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Center for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands PDF Version (175 KB) Abstract About This Article Supplemental Material Background: Recently, there has been increasing evidence that exposure to air pollution is linked to neurodegenerative diseases, but little is known about the association with amyotrophic lateral sclerosis (ALS). Objectives: We investigated the association between long-term exposure to air pollution and risk of developing ALS. Methods: A population-based case–control study was conducted in Netherlands from 1 January 2006 to 1 January 2013. Data from 917 ALS patients and 2,662 controls were analyzed. Annual mean air pollution concentrations were assessed by land use regression (LUR) models developed as part of the European Study of Cohorts for Air Pollution Effects (ESCAPE). Exposure estimates included nitrogen oxides (NO2, NOx), particulate matter (PM) with diamete...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

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Conclusions: Smoking and substance abuse are common among industrial workers. Tramadol and cannabis are the most commonly abused substances. Smoking, older age, and male sex are correlates of substance abuse. Alcohol abuse is associated with dependence.
Source: Addictive Disorders and Their Treatment - Category: Addiction Tags: Original Articles Source Type: research
Conclusions: These findings show that in Brazil problems related to alcohol use by the elderly remain relatively unknown. There was a high heterogeneity of methodologies in the studies, making it difficult to summarize the findings and produce prevalence estimates for the different patterns of consumption. More homogenous studies using similar definitions of patterns of alcohol consumption are required to allow comparisons to be made between different Brazilian regions and other countries.
Source: Addictive Disorders and Their Treatment - Category: Addiction Tags: Original Articles Source Type: research
Authors: Forester BP, Rahman AT, Harper DG, Petrides G PMID: 31734085 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
Abstract The Power of Food Scale (PFS) is an instrument designed to examine individual differences in the drive to eat for pleasure (as opposed to in response to physiological hunger) and the effect of living in an obesogenic environment. Previous research supports the validity and reliability of the PFS, however, it had yet to be validated in an ethnically diverse college sample. The purpose of the current study was to test the factor structure and measurement invariance of the PFS across gender, ethnicity, and weight status. A sample of 432 college students completed the PFS (males=113, females = 319; non-Hispan...
Source: Eating Behaviors - Category: Eating Disorders & Weight Management Authors: Tags: Eat Behav Source Type: research
In conclusion, HFD-induced hypertension is not driven by increased sympathetic neurotransmission to MA in male and female Dahl ss rats. PMID: 31731103 [PubMed - in process]
Source: Autonomic Neuroscience - Category: Neuroscience Authors: Tags: Auton Neurosci Source Type: research
Publication date: Available online 18 November 2019Source: Physics of the Earth and Planetary InteriorsAuthor(s): Jianshe Lei, Dapeng Zhao, Xiwei Xu, Mofei Du, Qi Mi, Mingwen LuAbstractThe Tanlu fault zone is the most significant active fault in eastern China, which generated the great 1668 Tancheng earthquake (M 8.5). It is still unclear whether or not there is a link between the great earthquake generation and the upper-mantle structure. To address this issue, we study P-wave upper-mantle tomography beneath eastern China using 44,047 teleseismic P-wave arrival times. Our results show that at depths
Source: Physics of the Earth and Planetary Interiors - Category: Physics Source Type: research
Authors: Liu X, Yang G, Huang J, Chai L, Liu X, Dai Q, Yang Z Abstract Aim: KRAS SNPs may increase KRAS transcription and KRAS levels. SNPs of KRAS 3'UTR can affect carcinoma risk and prognosis. Materials &methods: The rs8720 and rs7960917 in KRAS 3'UTR for colorectal carcinoma (CRC) risk and survival were investigated in a case-control study. Association between SNPs and CRC risk, survival analysis were analyzed by an unconditional logistic regression model, log-rank test, Kaplan-Meier estimation, Cox regression model and one-way analysis of variance. Results &conclusion: The genotype CT of rs8720 was sign...
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Conclusion: Total EMPs per microliter PFP, percent-activated EMPs and percent LACT(+) of total EMPs are reproducible among youth. PMID: 31729246 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02334H, PaperChun-Xue Yu, Ru-Yue Wang, Feng-Ming Qi, Pan-Jie Su, Yi-Fan Yu, Bing Li, Ye Zhao, Dejuan Zhi, Zhan-Xin Zhang, Dong-Qing Fei Eupulcherol A (1), a novel triterpenoid with an unprecedented carbon skeleton, was isolated fromEuphorbia pulcherrima. Its structure was determined by comprehensive analysis of spectroscopic data, including HRESIMS, 1D and... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
CONCLUSION: Starting to drink alcohol in the early teen years predicted current alcohol use, current binge drinking and mixing of alcohol with energy drinks when students were in Grade 12. Findings indicate a need for development of novel alcohol prevention efforts. PMID: 31729312 [PubMed - in process]
Source: Health Promotion and Chronic Disease Prevention in Canada - Category: International Medicine & Public Health Tags: Health Promot Chronic Dis Prev Can Source Type: research
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