Implanted Islets: From the POV of a Longtime Type 1

We shared the news early this year about the exciting work happening at City of Hope, after the Wanek Family in Wisconsin donated millions to diabetes cure research at the California facility. Today, we're excited to hear a first-hand POV from a l...
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs

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Increased odds of inflammatory bowel disease, type 1 diabetes, VTE seen before RA diagnosis versus controls
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Cardiology, Endocrinology, Family Medicine, Gastroenterology, Internal Medicine, Neurology, Pulmonology, Rheumatology, Journal, Source Type: news
Publication date: Available online 19 November 2019Source: Chemical Engineering Research and DesignAuthor(s): Katarzyna Skrzypek, Efrem Curcio, Dimitrios StamatialisAbstractWidespread application of islet transplantation as a cure for type 1 Diabetes Mellitus patients is limited mainly due to the need for life-long immunosuppression associated with serious side effects. Immunoisolation by encapsulation of islets in semi-permeable membranes may overcome this issue as it allows for transplantation potentially obviating the need for immunosuppressive drug therapy.This work focuses on the development and validation of a model ...
Source: Chemical Engineering Research and Design - Category: Chemistry Source Type: research
Abstract Regulatory T cells (Tregs) play a central role in the induction and maintenance of immune homeostasis and self-tolerance. Tregs constantly express the high-affinity receptor to IL-2. IL-2 is a pleiotropic cytokine and a key survival factor for Tregs. It maintains Tregs' suppressive function by promoting Foxp3 expression and subsequent production of immunoregulatory cytokines. Administration of low-dose IL-2 is shown to be a promising approach to prevent allograft rejection and to treat autoimmune and inflammatory conditions in experimental models. The combination of IL-2 with its mAb (JES6-1) has also bee...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
WEDNESDAY, Nov. 20, 2019 -- There are associations between rheumatoid arthritis (RA) and multiple comorbidities before and after diagnosis, with inflammatory bowel disease, type 1 diabetes, and venous thromboembolism (VTE) occurring more often...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Publication date: Available online 19 November 2019Source: Journal of Functional FoodsAuthor(s): Lucía Diez-Gutiérrez, Leire San Vicente, Luis Javier R. Barrón, María del Carmen Villarán, María ChávarriAbstractProbiotics have attracted growing interest in recent decades due to their multiple health benefits. The synergistic relationship between probiotics and prebiotics can enhance the production of metabolites called postbiotics, which are gaining increasing importance because of their beneficial functions in the gastrointestinal tract and their influence on different organ...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
This study is the first to examine the contribution of the HLA-DR/DQ alleles and haplotypes to T1D susceptibility in Jordanians. METHODS: Polymerase chain reaction sequence-specific primers (PCR-SSP) were used to genotype 41 Jordanian healthy controls and 50 insulin-dependent diabetes mellitus (IDDM) patients. RESULTS: The following alleles were found to be significant high risk alleles in T1D Jordanian patients: DRB1*04 (OR=3.95, p
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
WEDNESDAY, Nov. 20, 2019 -- People with inflammatory bowel disease, type 1 diabetes or blood clots may be at increased risk for rheumatoid arthritis -- and people with rheumatoid arthritis are at added risk for heart disease, blood clots and sleep...
Source: - Daily MedNews - Category: General Medicine Source Type: news
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Stand up paddle boarding (SUP) is a growing sport, and Wylde is already a superstar in it.
Source: Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
ConclusionsFrequent LTPA is associated with a lower incidence of severe diabetic retinopathy during the follow-up. The total amount or the other components of LTPA (intensity or duration of a single session) were not associated with severe diabetic retinopathy.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
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