George Huntley: Songwriter, Half-Marathoner, Box-Making Expert, Diabetes Advocate

Meet George Huntley, a longtime type 1 who you can pretty much think of as a "professional volunteer" in diabetes advocacy. OK, we made that title up, but it's apropos given what this Indianapolis D-peep has been lending his free time and passion ...
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs

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Condition:   Type1diabetes Intervention:   Sponsor:   LMC Diabetes & Endocrinology Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The FDA advisers said the pivotal approval study was too short and did not involve enough patients to characterize efficacy or safety.Medscape Medical News
Source: Medscape Pharmacist Headlines - Category: Drugs & Pharmacology Tags: Diabetes & Endocrinology News Source Type: news
Funding Opportunity RFA-DK-19-506 from the NIH Guide for Grants and Contracts. Type 1 diabetes (T1D) is a serious and burdensome chronic disease that usually onsets in childhood or early adulthood. Recent progress in clinical trials and understanding of T1D pathogenesis and mechanisms have created opportunities to delay the onset and progression of the disease. This supplement is intended to provide resources for the design and conduct of new intervention studies in individuals at early pre-clinical stages of T1D and in individuals with new-onset T1D through the T1D TrialNet network (TrialNet). This Funding Opportunity An...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Series Type : Other ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Martin G Scherm ; Carolin Daniel ; Benedikt KirchnerSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensIn type 1 diabetes (T1D), the appearance of multiple islet autoantibodies indicates the onset of islet autoimmunity, often many years before clinical symptoms arise. However, the underlying molecular mechanisms in T cells that can promote aberrant activation thereby triggering autoimmune progression remain poorly understood. Here, we show that during early stages of islet autoimmunity a miRNA142-3p/Tet2 signaling axis in murine and human CD4+T cells interferes with th...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Martin G Scherm ; Carolin Daniel ; Jonathan SchugSeries Type : OtherOrganism : Homo sapiensIn type 1 diabetes (T1D), the appearance of multiple islet autoantibodies indicates the onset of islet autoimmunity, often many years before clinical symptoms arise. However, the underlying molecular mechanisms in T cells that can promote aberrant activation thereby triggering autoimmune progression remain poorly understood. Here, we show that during early stages of islet autoimmunity a miRNA142-3p/Tet2 signaling axis in murine and human CD4+T cells interferes with the efficient induction of regulatory T (Treg) cells a...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Independent experts on an FDA advisory panel on Wednesday voted against the use of an already approved diabetes drug from Eli Lilly and Co and Boehringer Ingelheim as an add-on to insulin therapy in patients with type 1 diabetes.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Nature Reviews Nephrology, Published online: 14 November 2019; doi:10.1038/s41581-019-0229-1A new genome-wide association study of patients with type 1 diabetes mellitus reveals novel loci that are associated with the development of diabetic kidney disease. The most significant of these loci encodes the α3 chain of type IV collagen, which is an important component of the glomerular basement membrane.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research
AbstractPurpose of ReviewTo shed light on the multiple factors impacting a decline in pancreas transplant volume and to present strategies that individual transplant centers can implement to increase their volumes.Recent FindingsOverall, pancreas transplant volume is declining in the USA and in several other countries of the world. The reasons are multifactorial, but an important driving factor is the delayed progression to end-stage renal disease in patients with type 1 diabetes due to better diabetes care. Another factor contributing to the lack of expansion of the pancreas transplant field is an under appreciation by th...
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research
Conclusions/interpretationHigher plasma ascorbic acid levels may protect against islet autoimmunity in children genetically at risk for type 1 diabetes. Further studies are warranted to confirm these findings.Data availabilityThe datasets generated and analysed during the current study will be made available in the NIDDK Central Repository athttps://www.niddkrepository.org/studies/teddy.
Source: Diabetologia - Category: Endocrinology Source Type: research
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