Ask D'Mine: Easter Candy Edition

Welcome back to our weekly diabetes advice column, Ask D'Mine - with your host veteran type 1 and diabetes author Wil Dubois. This weekend is Easter, so it just stands to reason that Wil's fielding a question about how to choose the "least offensi...
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs

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This study compared extracted structured EHR data to chart review from endocrinologists’ healthcare records at a large, academic ambulatory hospital in Ontario, Canada.MethodsConsecutive chart review for the first 10 patients with either type 1 or type 2 diabetes seen between January 1st, 2015 and March 1st, 2016, were sampled for each of the 10 endocrinologists within the diabetes program, and electronic data extraction was also completed for a core set of structured diabetes care elements. Fischer Exact test was used to determine differences in data availability between extracted EHR data to chart review.ResultsOut...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
CONCLUSION: FGF21 prevents renal fibrosis via negative regulation of the TGF-β/Smad2/3-mediated EMT process by activation of the Akt/MDM2/p53 signaling pathway. PMID: 31701691 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
AbstractPurpose of ReviewIndividuals with type 1 and type 2 diabetes mellitus (T1DM, T2DM) have an increased risk of bone fracture compared to non-diabetic controls that is not explained by differences in BMD, BMI, or falls. Thus, bone tissue fracture resistance may be reduced in individuals with DM. The purpose of this review is to summarize work that analyzes the effects of T1DM and T2DM on bone tissue compositional and mechanical properties.Recent FindingsStudies of clinical T2DM specimens revealed increased mineralization and advanced glycation endproduct (AGE) concentrations and significant relationships between mecha...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
Conclusions/interpretationOur study indicates that incident diabetes in adults has an element of autoimmune aetiology. Thus, there might be a reason to re-evaluate the present subclassification of diabetes in adulthood.
Source: Diabetologia - Category: Endocrinology Source Type: research
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
ConclusionSummarized crude risk estimates showed a small increased T1D risk in children and young adults born through elective CS compared to vaginal delivery, but with significant heterogeneity. Adjusted risk estimates by study design indicated a slightly increased T1D risks associated with elective or non-elective CS.
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
This study aims at the fabrication and evaluation of alginate-chitosan microcapsules encapsulating insulin-secreting beta-TC-6 cells using an automated spraying nozzle. Uniform spherical microcapsules (250-350 µm) encapsulated with beta-TC-6 cells were fabricated in large quantities in a short span of time. Microencapsulated beta-TC-6 cells were transplanted intraperitoneally into streptozotocin (STZ) induced diabetic mice and monitored for immune tolerance and decrease in blood glucose levels. Mice that received microencapsulated beta-TC-6 cells maintained normoglycemia for 35±5 days before rejection. However...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
ConclusionsThese results reflect adaptive WM-processing mechanisms in which cognitive strategies have evolved in T1D patients in order to meet task demands.
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
Publication date: Available online 9 November 2019Source: Journal of Molecular BiologyAuthor(s): Eckhard Lammert, Peter ThornAbstractThe islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and are complex micro-organs embedded within the larger volume of the exocrine pancreas. Humans can have ∼3.2 million islets [1] which, to our current knowledge, function in a similar manner to sense circulating blood glucose levels and respond with the secretion of a mix of different hormones that act to maintain glucose concentrations around a specific set point [2]. At a cellular level the control...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
BACKGROUND: The prevalence of adults with Type 1 diabetes (T1D) is increasing, and their risk of cardiovascular disease is high. Comorbid diabetes distress and depressive symptoms may affect their cardiovascular health. OBJECTIVES: The purpose of t...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
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