Adam Brown: Diabetes Bright Spots and Landmines (with Book Giveaway!)

When does a book go beyond being just "a good read"? When it changes how you think and allows you to learn more about yourself, for one thing. That's how I feel about the new title Bright Spots&Landmines written by fellow type 1 D-peep Adam ...
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs

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Abstract In recent years, there have been exciting new insights into pathogenesis of type 1 diabetes in a number of areas of immunology. In this edition, a collection of four review articles are presented, which encompass new findings presented at the Immunology of Diabetes Society meeting in London 2018. The articles are focused particularly in 4 related areas of investigation, which include autoantibodies in type 1 diabetes, new autoantigenic targets for CD4 T cells, trafficking of immune cells to the pancreas and islet-immune interactions in the pancreas. PMID: 31729755 [PubMed - in process]
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research
Conclusions: The results show that GLP-1 infusion suppresses the postprandial secretion of gastrin in normal subjects and even more so in the diabetes patients. The results may therefore shed further light on the upper gastrointestinal side effects of GLP-1-derived drugs in diabetic patients. PMID: 31725337 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
This study aimed to investigate the risk behaviors of adolescents with T1D and the effect of orthorexic eating behaviors (OEB) on glycemic control (GC). Methods: This cross-sectional study was conducted with 107 adolescents with T1D who were between 13-18 years of age and attended high school. The risk behavior scale (RBS) and orthorexic behavior scale (ORTO-11) were administered to the participants. A high RBS score indicates risky behavior; a low ORTO-11 score suggests a tendency to OEB. At the same time, participants were tested for GC and categorized as optimal GC (HbA1c ≤7%) or poor GC (HbA1c>7%). Result...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research
Authors: Eleftheriadou I, Didangelos T, Pappas AC, Anastasiou E, Vasilopoulos C, Zoupas C, Manes C, Tsatsoulis A, Benroubi M, Pangalos E, Thomakos P, Gerasimidi-Vazeou A, Tentolouris N Abstract PURPOSE: To assess the efficacy of a real-time continuous glucose monitoring (RT-CGM) system added to insulin pump therapy for 3 months, in sub-optimally controlled adults with type 1 diabetes mellitus (T1D). METHODS: This was a prospective, multicenter, non-randomized, post-market release study. A total of 43 adult patients with T1D on insulin pump therapy and inadequate glycemic control (HbA1c> 7.0%) participated in...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
Conditions:   Type 1 Diabetes;   Type 1 Diabetes Mellitus;   Hyperglycemia, Postprandial Interventions:   Drug: Fiasp;   Drug: Pramlintide Acetate;   Drug: Placebo;   Device: Artificial Pancreas Sponsors:   McGill University;   Juvenile Diabetes Research Foundation Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Type 1 Diabetes Intervention:   Sponsor:   Translational Research Institute for Metabolism and Diabetes, Florida Not yet recruiting
Source: - Category: Research Source Type: clinical trials
TYPE 1 and type 2 diabetes are two well established conditions that affect a person ’s blood sugar control. But another type of diabetes, type 1.5 diabetes, is beginning to gain traction - what is it, and are you at risk?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Kidney disease caused by type 1 diabetes can progress to end stage renal disease and can increase mortality risk. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) plays a major role in producing oxidative stress in the kidney in diabetes, and its activity is attenuated by GKT137831, an oral Nox inhibitor with predominant inhibitory action on Nox-1 and Nox  − 4. Previous studies have demonstrated renoprotective effects with GKT137831 in various experimental models of type 1 diabetes-related kidney disease.
Source: Contemporary Clinical Trials - Category: Radiology Authors: Source Type: research
ConclusionsOur study constitutes the first functional study ofPtpn22 in B cells in NOD mice. Our findings suggest thatPtpn22 variation contributes to T1D by modifying the B cell compartment and support a gain-of-function for thePTPN22 disease variant.
Source: Endocrine - Category: Endocrinology Source Type: research
Condition:   Type1diabetes Intervention:   Sponsor:   LMC Diabetes & Endocrinology Ltd. Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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