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US and UK researchers launch trial to study treatment approaches for multiple sclerosis

Researchers at the University of Nottingham and Nottingham University Hospitals NHS Trust, UK, have collaborated with a team from the Cleveland Clinic in Ohio, US, for a clinical trial for the treatment of multiple sclerosis (MS).
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news

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This study aimed to perform a systematic review and meta-analysis on the association between vitamin D levels and AA.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Research letter Source Type: research
Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Koos J. F. van Dorst, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Condition:   Multiple Sclerosis Intervention:   Device: Myo Armband (MYO,Thalamic Labs Inc, Kitchener, ON, Canada) Sponsor:   Nantes University Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Multiple Sclerosis Intervention:   Other: Composite severity score calculation Sponsor:   Institut National de la Santé Et de la Recherche Médicale, France Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: None of the DMDs were found to be cost-effective in the treatment of RRMS at a WTP threshold of $100000 in this analysis. The DMDs would only be cost-effective at a WTP above $300000.  LIMITATIONS: The current analysis did not reflect the Saudi population preference in valuation of health states and did not consider the societal perspective in terms of cost.   
Source: Annals of Saudi Medicine - Category: General Medicine Tags: ISSUE 6 Source Type: research
Combined central and peripheral demyelination (CCPD) is a rare autoimmune demyelinating disorder affecting both CNS and peripheral nervous system (PNS). Prevalence is probably underestimated, since in relapsing-remitting multiple sclerosis (MS)–like forms the PNS involvement is frequently undetected. The pathogenesis is largely unknown, prognosis is poor, and treatment options, including steroids and IV immunoglobulins (IVIg), are limited and almost ineffective.1–3
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: All Clinical Neurology, Chronic inflammatory demyelinating polyneuropathy, All Demyelinating disease (CNS) Case Source Type: research
A diet rich in fruits, vegetables, and whole grains may significantly improve symptoms for people with multiple sclerosis, researchers report.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Multiple Sclerosis Source Type: news
Authors: Russo M, Calamuneri A, Cacciola A, Bonanno L, Naro A, Dattola V, Sessa E, Buccafusca M, Milardi D, Bramanti P, Calabrò RS, Quartarone A Abstract The present study is aimed at further exploring structural and functional correlates of fatigue in Relapsing- Remitting Multiple Sclerosis (RRMS) patients by using a combined approach by means of transcranial magnetic stimulation (TMS) and a Diffusion Tensor Imaging (DTI). The physiopathology of fatigue in MS is still poorly understood, although a variety of pathogenic mechanisms has been proposed. Our working hypothesis is that diffuse microstructural whit...
Source: Archives Italiennes de Biologie - Category: Neuroscience Tags: Arch Ital Biol Source Type: research
BACKGROUND: In recent times, increasing safety concerns have been associated with the use of mobile phones by pedestrians. In particular, texting has been shown to significantly alter gait patterns. However, no specific investigations have been performed o...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news
Authors: Matilla-Dueñas A, Corral-Juan M, Rodríguez-Palmero Seuma A, Vilas D, Ispierto L, Morais S, Sequeiros J, Alonso I, Volpini V, Serrano-Munuera C, Pintos-Morell G, Álvarez R, Sánchez I Abstract More than 600 human disorders afflict the nervous system. Of these, neurodegenerative diseases are usually characterised by onset in late adulthood, progressive clinical course, and neuronal loss with regional specificity in the central nervous system. They include Alzheimer's disease and other less frequent dementias, brain cancer, degenerative nerve diseases, encephalitis, epilepsy, geneti...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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