Atrichia with Papular Lesions: Importance of Histology at an Early Disease Stage
We report the case of a 5-year-old girl born from consanguineous parents, presenting with alopecia universalis since the age of 8 months, without papules or cysts over the scalp or body. The goal of this paper is to emphasize the relevance of histopathology for the early diagnosis of atrichia with papular lesions in children with alopecia universalis, in settings where genetic testing may not be available.Skin Appendage Disord 2018;4:129-130
Recent studies have demonstrated significant molecular parallels between atopic dermatitis and alopecia areata as predominantly TH2 ‐mediated diseases. This case report highlights the potential for Dupilumab as a targeted biologic therapy in both atopic dermatitis and alopecia areata. AbstractRecent studies have demonstrated significant molecular parallels between atopic dermatitis and alopecia areata as predominantly TH2 ‐mediated diseases. This case report highlights the potential for Dupilumab as a targeted biologic therapy in both atopic dermatitis and alopecia areata.
Conclusion: This study suggests that the current AA prevalence in the US is similar to the upper estimates from the 1970s at approximately 0.21% (700,000 persons) with the current prevalence of "moderate to severe" disease at approximately 0.09% (300,000 persons). Given this prevalence and the substantial impact of AA on quality of life, the burden of AA within the US is considerable. PMID: 32280257 [PubMed]
PMID: 32285135 [PubMed - as supplied by publisher]
ConclusionCyclosporine in combination with oral systemic corticosteroids is more effective than in monotherapy for severe alopecia areata.
No abstract available
Conditions: Alopecia Areata; Alopecia Totalis; Alopecia Universalis Interventions: Drug: Fecal material transfer therapy; Procedure: 4mm Punch Biopsy of Scalp; Diagnostic Test: Blood draw; Procedure: Skin Microbiome sampling; Procedure: Hair Microbiome Sampling; Drug: Pre-FMT Antibiotic Cocktail; Drug: Bowel Prep Sponsor: Columbia University Not yet recruiting
Authors: Parlikar R, Selvaraj S, Shiva L, Sreeraj VS, Venkatasubramanian G, Chandra PS PMID: 31896886 [PubMed]
ConclusionFor alopecia in children, regional immunotherapy has been recommended in the treatment guidelines. However, the condition can recur after discontinuation of treatment and there is no treatment uniformity. The present findings suggest that Kampo medicine might be appropriate for alopecia universalis considering treatment continuity and safety.
Conclusions There was a significant relation between the severity of alopecia and treatment outcome. (p=0.038) Patients with alopecia areata had significantly better response when compared to alopecia totalis and universalis. There was no statistically significant relation with other parameters such as disease duration, age, gender, atopy history, age of onset, and histopathological features. PMID: 31655499 [PubMed - as supplied by publisher]
Ichthyosis with confetti (IWC) is a genodermatosis characterized by congenital erythroderma and the systematic development of epidermal pale spots not described in other genodermatoses. All IWC patients are carriers of a heterozygous keratin (KRT)10 or KRT1 variant leading to a shifted reading frame and the translation of an aberrant carboxyl (C)-terminus. The aberrant KRT10/KRT1 protein is localized in the nucleus instead of the cytoplasm. 20 years ago, 2 patients with an IWC-like phenotype were described to suffer from MAUIE (micropinnae, alopecia universalis, ichthyosis, ectropion) syndrome.