Polysomnographic findings in craniopharyngioma patients
AbstractPurposeThe purpose of this study is to evaluate whether damage to the hypothalamus due to craniopharyngioma or consequent surgery may involve the sleep-wake regulatory system, resulting in sleep disturbances and sleepiness.MethodsSeven craniopharyngioma patients and 10 healthy controls were evaluated with sleep questionnaires including the Epworth Sleepiness Scale, polysomnography, and a multiple sleep latency test (MSLT). Five patients and eight controls had lumbar puncture performed to determine hypocretin-1 levels.ResultsPatients tended to feel sleepier than control individuals of the same age (p = 0.09). No subjects had symptoms of hypnagogic hallucinations, sleep paralyses, or cataplexies. Four patients and one control had periodic leg movements (PLMs). One patient had fragmented sleep pattern, rapid eye movement (REM) sleep without atonia, and PLMs. One patient had short sleep periods during the daytime. Four patients had fragmented sleep pattern. With the MSLT, four patients and two controls had mean sleep latency of
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Publication date: Available online 10 October 2020Source: IJC Heart &VasculatureAuthor(s): Dominik Linz, Jeroen Hendriks
Background: Obesity is strongly associated with both Blount disease and obstructive sleep apnea (OSA). Obesity increases risks for anesthetic and postoperative complications, and OSA can further exacerbate these risks. Since children with Blount disease might have both conditions, we sought to determine the perioperative complications and the prevalence of OSA among these children. Methods: Patients younger than 18 years undergoing corrective surgery for Blount disease were identified from 2 sources as follows: a retrospective review of records at a single institution and querying of the Kids’ Inpatient Database...
Publication date: Available online 9 October 2020Source: Molecular MetabolismAuthor(s): Xiao Tan, Lieve van Egmond, Jonathan Cedernaes, Christian Benedict
Date: Thursday, 10 08, 2020; Speaker: Craig Heller, Ph.D., Stanford University; Sigrid Veasey, M.D., University of Pennsylvania; Colleen McClung, Ph.D., University of Pittsburgh; Gary Aston-Jones, Ph.D., Rutgers University; Thomas Kilduff, Ph.D., SRI International, ; Ryan Logan, Ph.D., University of Pittsburg; Carol Everson, Ph.D., Medical College of Wisconsin; Xiaoke Chen, Ph.D., Stanford University ; Michael T. Smith, Ph.D., Johns Hopkins University; Henry Yaggi, M.D., Yale University ; Andre Huhn, Ph.D., Johns Hopkins University ; Mark Greenwald, Ph.D., Wayne State; Scott Bunce, Ph.D., Penn State University ; Johanna El...
DR MICHAEL MOSLEY: Now, lots of people have a late-night tipple because they believe that alcohol helps them sleep better. But recent research shows quite clearly that this is a myth.
Conclusions: Bioinformatics analysis is a useful tool to explore the mechanism and pathogenesis of PHN. The identified hub genes may participate in the onset and development of PHN and serve as therapeutic targets. PMID: 33029266 [PubMed - in process]
Conditions: Obstructive Sleep Apnea of Adult; Periodontal Diseases; Periodontal Pocket; Periodontal Attachment Loss Intervention: Sponsor: I.M. Sechenov First Moscow State Medical University Not yet recruiting
Condition: Post-traumatic Stress Disorder Interventions: Behavioral: Sleep recording; Behavioral: Cognitive tasks; Other: Questionnaires Sponsor: Direction Centrale du Service de Santé des Armées Not yet recruiting
ConclusionsThis study describes the prevalence and associated predictors of hypersomnia for patients with craniopharyngioma after surgical resection. HI was predictive of narcolepsy diagnosis, and a higher body mass index z-score was associated with hypersomnia due to medical condition and narcolepsy. We recommend that sleep assessment and intervention begin after surgical resection, especially in overweight or obese patients and those with extensive tumors.