Effects of duloxetine on pain and walking distance in neuropathic pain models via modulation of the spinal monoamine system

ConclusionsThese findings suggest that the analgesic effects of duloxetine are mainly mediated by the spinal monoamine system, independent of the antidepressant effects of this agent. SignificanceThe findings of this study suggest that duloxetine may be an effective treatment of broad neuropathic pain states, including neuropathic low back pain. The analgesic effects of duloxetine might be mediated by alterations of the descending pain modulatory pathways in the spinal cord, independent of the antidepressant effects.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research