Novel interactions of two α-Hb variants with SEA deletion α(0)-thalassemia: hematological and molecular analyses.

CONCLUSIONS: Identification of the patients confirmed that interaction of these rare Hb variants with α(0)-thalassemia does not lead to the Hb H disease. Differentiation of these two Hb variants from other clinically relevant hemoglobinopathies in a routine setting is, however, necessary. This can be accomplished using a combined Hb-HPLC and CE analysis followed by PCR-RFLP assays. PMID: 28945175 [PubMed - as supplied by publisher]
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research