Pfizer helps pump $103M into startup to develop new cancer therapies

A New York startup has been spun-out of Pfizer to develop clinical-stage experimental therapies. Nascent medicine company SpringWorks Therapeutics completed a $103 million series A round led by the New York-based pharma giant with the help of Bain Capital, OrbiMed and LifeArc (formerly known as MRC Technology). Pfizer (NYSE: PFE) granted SpringWorks the rights to help develop four drugs or t herapies that treat various conditions, including post-traumatic stress disorder and cancer. Another New…
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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Source: Pediatric Hematology and Oncology - Category: Pediatrics Authors: Source Type: research
Epigenetics refers to the study of a natural phenomenon and to the phenomenon itself. Epigenetics is the study of the mechanisms that turn on and off the expression of our genes without altering the DNA sequence. Epigenetics is also used to refer to the changes in expression of our genes. Factors such as age, nutritional habits, psychological stress, physical activity, working habits and substance abuse can trigger changes in gene expression (Alegría-Torres, 2011). These changes in gene expression, epigenetics, happen all the time in the natural world. For example, two identical twins, born with the exact same DNA s...
Source: Psych Central - Category: Psychiatry Authors: Tags: Abuse Children and Teens Genetics Neuroscience PTSD Trauma Child Abuse child neglect Childhood Trauma epigenetics gene expression Transgenerational trauma Source Type: news
AbstractCannabinoid receptors, endocannabinoids and the enzymes responsible for their biosynthesis and degradation constitute the endocannabinoid system. In recent decades, the endocannabinoid system has attracted considerable interest as a potential therapeutic target in numerous pathological conditions. Its involvement in several physiological processes is well known, such as in energy balance, appetite stimulation, blood pressure, pain modulation, embryogenesis, nausea and vomiting control, memory, learning and immune response, among others, as well as in pathological conditions where it exerts a protective role in the ...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
ConclusionsResults provide partial support for the cognitive processing model of FCR. Psychological factors were found to play an important role in FCR morbidity after controlling for demographic/medical factors. More intrusive thoughts and negative beliefs about worry were strong independent predictors of FCR morbidity. Cancer survivors with clinically significant FCR may benefit from assessment for intrusive thoughts and metacognitions and delivery of trauma- and/or metacognitive-based interventions accordingly.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
People catch colds because they were exposed to a virus or infection.   Some people get cancer because cells have begun endlessly dividing in their body. We get itchy because an irritant has affected our skin.   We get hungry because our body needs nourishment on a regular basis, or thirsty because we aren’t sufficiently hydrated. I could go on and on … usually the things that we experience in our daily lives are a cause and effect thing; this happens because that happened, and so on. PTSD is similar, but also so very different. It happens when someone has experienced a traumatic event and...
Source: Psych Central - Category: Psychiatry Authors: Tags: Personal Stories PTSD Trauma Abusive Relationship Domestic Violence Spousal Abuse triggers Source Type: news
CONCLUSION: Adolescent and young adult cancer survivors who were older and had established strong relationships with health professionals at the clinic were more able to narrate their experiences, display a positive comprehension of the events with a pragmatic acceptance of the follow-up procedures. Relationships with health professionals should therefore be monitored and improved, both during the cancer treatment and in the off-therapy period. The narrative technique allows adolescent and young adult cancer survivors to reorganize and give shape to their traumatic experience. PMID: 30322502 [PubMed - in process]
Source: European Journal of Oncology Nursing - Category: Nursing Authors: Tags: Eur J Oncol Nurs Source Type: research
Abstract BACKGROUND: The psychological distress caused by cancer can remain long after remission. With advanced curative treatments, many pediatric patients continue to have late complications that interfere with neurologic, physical, and social development. OBJECTIVES: The aim of this article is to analyze nine published articles that focus on adolescent cancer survivors (ACSs) and the incidence and risk factors of post-traumatic stress disorder (PTSD) and post-traumatic stress symptoms (PTSSs). METHODS: A search of published articles including pediatric and adolescent oncology and PTSD was performed. T...
Source: Clinical Journal of Oncology Nursing - Category: Nursing Authors: Tags: Clin J Oncol Nurs Source Type: research
Few studies have captured the unique ways in which cancer affects the growth and development of adolescent and young adult cancer survivors. This paper illustrates the daily life of childhood cancer survivors who are now adolescents and young adults, their post-traumatic growth and follow-up perceptions, adopting a narrative approach.
Source: European Journal of Oncology Nursing - Category: Cancer & Oncology Authors: Source Type: research
The deadly truth about cancer in the fire service will be front and center September 15 as fire fighters and paramedics from across the United States and Canada join grieving families at the IAFF Fallen Fire Fighter Memorial in Colorado Springs, Colorado, to honor those who have lost their lives in the line of duty.   The names of 271 fire fighters who have died in the line of duty from trauma or occupational illness will be etched on to the granite Wall of Honor. The risk of traumatic death in the fire scene has declined over the years – in large part due to the International Association of Fire Fighters’...
Source: JEMS: Journal of Emergency Medical Services News - Category: Emergency Medicine Tags: News Administration and Leadership Source Type: news
More research is done on the therapeutic benefits of dogs than on cats and other animals. But there are signs of change.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Animal Behavior Service Dogs and Other Animals Cats Therapy and Rehabilitation Post-Traumatic Stress Disorder Autism Mental Health and Disorders Cancer Breast Cancer Source Type: news
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