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Auris Medical concludes enrolment in Phase III trial of Keyzilen for tinnitus

Swiss biopharmaceutical firm Auris Medical has concluded patient enrolment in a Phase III clinical trial (TACTT3) of its product candidate Keyzilen to treat acute and post-acute inner ear tinnitus.
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news

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Conclusions: OCF is rare in children but is associated with head, thoracic, and abdominal trauma. Type I and II fractures predominate. Although operative treatment rarely is necessary, it is required in patients with atlantooccipital dislocation. Ligamentous structures should be assessed with MRI.
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: SPECIAL FOCUS: Pediatric Orthopaedic Rotation Source Type: research
We examined demographic variables; tinnitus measured by health examination; and stress, depression, and suicidal ideation measured by health interview. RESULTS: The prevalence of tinnitus was 18.0%. Tinnitus severity was directly related to level of stress (p=0.023), depression (p
Source: Central European Journal of Public Health - Category: International Medicine & Public Health Tags: Cent Eur J Public Health Source Type: research
In the last two decades, Brain stimulation has been frequently used for treating tinnitus with relatively good results; yet, many types of research are still needed to find the optimal parameters for stimulation. Transcranial electrical stimulation techniques (tES) were well developed and gained more popularity in tinnitus research especially tDCS, the transcranial direct current stimulation [1,2], while more recent studies have focused on transcranial random noise stimulation (tRNS) and highlighted its superior effects and safety [3].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
Abstract During the past several years, the rapid development of neuroimaging techniques has contributed greatly in the noninvasive imaging studies of tinnitus. The aim of the present study was to explore the brain anatomical alterations in patients with right-sided unilateral pulsatile tinnitus (PT) in the early stage of PT symptom using voxel-based morphometry (VBM) analysis. Twenty-four patients with right-sided pulsatile tinnitus and 24 age- and gender-matched normal controls were recruited to this study. Structural image data preprocessing was performed using VBM8 toolbox. Tinnitus Handicap Inventory (THI) sc...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
CONCLUSION: This study demonstrated that masked hypertension must be kept in mind if there is a complaint of tinnitus without any other obvious reason. PMID: 29683729 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Hypertension - Category: Cardiology Authors: Tags: Clin Exp Hypertens Source Type: research
Vaibhav Kumar Jain, Vivek Singh, Vikas Kannaujia, Priyadarshini Mishra, Rajendra Vishnu Phadke, Kumudini SharmaIndian Journal of Ophthalmology 2018 66(5):714-717 This case series aimed to review the significance of revisiting papilledema after successful cerebral venous sinus thrombosis (CVST) management with sinus angioplasty. Four patients presented with blurring and transient obscuration of vision with papilledema, headache, tinnitus, and vomiting. On magnetic resonance venography and digital subtraction angiography, chronic transverse sinus thrombosis was diagnosed for which patients underwent endovascular interventio...
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
thge Elizabet Paunović Following the Parma Declaration on Environment and Health adopted at the Fifth Ministerial Conference (2010), the Ministers and representatives of Member States in the WHO European Region requested the World Health Organization (WHO) to develop updated guidelines on environmental noise, and called upon all stakeholders to reduce children’s exposure to noise, including that from personal electronic devices. The WHO Environmental Noise Guidelines for the European Region will provide evidence-based policy guidance to Member States on protecting human health from noise originating from t...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Project Report Source Type: research
A small new Dutch study found men were more prone to hearing loss and ringing in the ears, or tinnitus, and that unlike women this risk was driven up further by other factors like drink and drugs.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
This study was an observation in Nimboran Subdistrict, Jayapura District, Papua Province, Indonesia during 2013. Thirty individuals from ‘Pengurus Rukun Tetangga’ group were chosen randomly for the survey. Facts evaluated were knowledge of cause of malaria, disease transmission, symptoms and complication, diagnosis, treatment and side effects, medical seeking behavior and treatment, vector breeding sites, and attitude towards compliance of malaria treatment and use of mosquito nets. Self-care against malaria was considered important by 65% of the respondents. All participants had visited health centers and comp...
Source: Southeast Asian Journal of Tropical Medicine and Public Health - Category: Tropical Medicine Tags: Southeast Asian J Trop Med Public Health Source Type: research
Abstract Hyperactive dysfunction may affect all cranial nerves in the posterior fossa. According to literature review and personal experience, hemifacial spasm was found to be associated not only with the most frequent cranial nerve syndromes, namely: trigeminal neuralgia, vago-glossopharyngeal neuralgia or VIIIth nerve disturbances manifested by vertigo, tinnitus, hearing decrease, but also with rarer syndromes like geniculate neuralgia, masticatory spasm etc. Also, a number of publications have pointed out the relatively high incidence of the coexistence of hemifacial spasm and systemic blood hypertension; both ...
Source: Neuro-Chirurgie - Category: Neurosurgery Authors: Tags: Neurochirurgie Source Type: research
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