Histopathologic study on mice infected with Plasmodium berghei after treatment with sulfadoxine-pyrimethamine, pyrimethamine, and hydroxychloroquine sulfate

AbstractMalaria, a disease caused by a parasitic protozoan belonging to the genusPlasmodium spp., is one of the common diseases in the tropical regions. Our aim in this study is to examine the effects of sulfadoxine-pyrimethamine, pyrimethamine, and hydroxychloroquine sulfate on the liver, spleen, and kidneys of treated mice withPlasmodium berghei. Mice were divided into five groups, of which three were infected with the parasite and treated with the aforementioned drugs. The other two groups were considered as negative (non-infected) and positive (infected) controls. The histopathological changes in the spleen among the different groups were observed and the highest change was in the pyrimethamine group. Prescribing these medications are necessary, especially for people who take these drugs in the long term, since these drugs may cause severe adverse effects.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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The objective of this study was to evaluate the in vitro antiplasmodial properties against malaria parasite in 15 plants mentioned in Indian traditional medicine texts.MethodsIn vitro antiplasmodial activity of methanolic extracts obtained from Indian traditional medicinal plants was evaluated on Plasmodium falciparum of FCK2 and INDO strains using schizont maturation inhibition assay and parasite lactate dehydrogenase inhibition assay.ResultsMethanolic extracts of Adhatoda zeylanica, Embelia ribes, Piper nigrum and Plumbago zeylanica exhibited more than 50% inhibition in both the stains in schizont maturation inhibition a...
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
In this study, we intend to explore linkage between organ specific immune response and eicosanoids. We suggest that eicosanoids (early immune modulators) and their organ specific expressions, possibly tune the outcome of mφ differently at different sites. We have observed that liver showed better containment of parasitic load than spleen, where we have found higher expression of 5-lipoxygenase (5-LO) enzyme along with IL-12 and iNOS. However, in spleen, enzymes of the PGE2 pathway (PGE2 cytosolic and PGE2 microsomal) along with IL-10 were predominantly higher. To further corroborate our findings, in vitro assays were c...
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
Authors: Savaş Şen Z, Taşar MA, Demirel Kaya F, Güneş A, Vezir E, Hızarcıoğlu Gülşen H Abstract Cryptosporidium spp. is one of the leading causes of parasitic diarrhea. It is the most common parasite in humans all over the world with Giardia. Cryptosporidium is an important cause of chronic diarrhea in Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) patients. Patients with normal immune system may have an asymptomatic course or clinical presentation such as acute watery diarrhea without blood and persistent diarrhea. The severity and duration of the disease may be a re...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Authors: Usluca S, Çelebi B, Babür C Abstract Toxoplasmosis is one of the most common parasitic infection in humans. Serological and molecular methods are used for diagnosis. Molecular methods are becoming increasingly preferred, since they lead to shortening of diagnostic time. In our study, it was aimed to determine Toxoplasma gondii by a cost-effective, quantitative, fast and reliable method without using a commercial kit, and apply method verification. T.gondii strain which was continued by mouse inoculation in our laboratory was used for method verification study. For this purpose DNA extraction wa...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Authors: Çulha G, Kaya T, Gülbol Duran G, Urhan Küçük M, Doğramacı AÇ, Tiyekli Çelik D Abstract Leishmaniasis is a parasitic disease that is transmitted to humans by the bites of infected female phlebotomine sandflies. In the diagnosis of cutaneous leishmaniasis (CL), in the smear samples, the demonstration of the parasite by microscope remains a gold standard method. However, it becomes difficult to diagnose the parasite since the number of amastigotes in chronic cases with a lesion of one year or longer is very low. Due to many factor such as patients primarily do not ...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Publication date: Available online 11 November 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Ander Burgaña Agoües, Rosa Abellana, Stanislav Zlatanov Yordanov, Rabee Kazan, A. Mauricio Pérez Ortiz, Cristina Castillo Ramos, Christian Garavito Hernández, Miriam Molina Rivero, Alessandra Queiroga Gonçalves, Emma Padilla, Josefa Pérez, Roger García Puig, Tomas M. Perez-PorcunaABSTRACTDientamoeba fragilis is a trichomonad parasite of the human intestine that is found worldwide. However, the biological cycle and transmission of this parasite ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - Category: Parasitology Source Type: research
Publication date: Available online 12 November 2019Source: Fish &Shellfish ImmunologyAuthor(s): Rosa León, María Ruiz, Yulema Valero, Constanza Cárdenas, Fanny Guzman, Marta Vila, Alberto CuestaAbstractAntimicrobial peptides (AMPs) form part of the innate immune response, which is of vital importance in fish, especially in eggs and early larval stages. Compared to antibiotics, AMPs show action against a wider spectrum of pathogens, including viruses, fungi and parasites, are more friendly to the environment, and do not seem to generate resistance in bacteria. Thus, we have tested in vitro the poten...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 10 November 2019Source: Veterinary ParasitologyAuthor(s): Fatemeh Khadir, Tahereh Taheri, Sima Habibzadeh, Farnaz Zahedifard, Elham Gholami, Maryam Heidari-Kharaji, Ahmad Oryan, Sima RafatiAbstractCutaneous leishmaniosis (CL) is a parasitic disease in animals and human with no satisfactory treatments and vaccination. Rapamycin is a potent inhibitor of mammalian target of rapamycin (mTOR) with various applications. Here, the effect of rapamycin alone or in combination with two other drugs, namely amphotericin B (AmB) and glucantime, was investigated against Leishmania tropica infection. In...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
This week's case is from Old One - illustrated by him and animated by his son. It features an arthropod that measures a few millimeters in length.See it in actionHERE!Identification?
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
Parasites genes prepare it for the unexpected, but could be exploited to fight the disease More at https://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=299535&WT.mc_id=USNSF_1 This is a Research News item.
Source: NSF Discoveries - Category: Science Source Type: research
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