The influence of MIR137 on white matter fractional anisotropy and cortical surface area in individuals with familial risk for psychosis

The rs1625579 variant near the microRNA-137 (MIR137) gene is one of the best-supported schizophrenia variants in genome-wide association studies (GWAS), and microRNA-137 functionally regulates other GWAS identified schizophrenia risk variants. Schizophrenia patients with the MIR137 rs1625579 risk genotype (homozygous for the schizophrenia risk variant) also have aberrant brain structure. It is unclear if the effect of MIR137 among schizophrenia patients is due to potential epistasis with genetic risk for schizophrenia or other factors of the disorder.

Source: Schizophrenia Research - September 25, 2017 Category: Psychiatry Authors: Bob O. Vogel, Tristram A. Lett, Susanne Erk, Sebastian Mohnke, Carolin Wackerhagen, Eva J. Brandl, Nina Romanczuk-Seiferth, Kristina Otto, Janina I. Schweiger, Heike Tost, Markus M. N öthen, Marcella Rietschel, Franziska Degenhardt, Stephanie H. Witt, An Source Type: research