Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging

Conclusions:
Multimodality brain imaging indicates sex differences in development of the AD endophenotype, suggesting that the preclinical AD phase is early in the female aging process and coincides with the endocrine transition of perimenopause. These data indicate that the optimal window of opportunity for therapeutic intervention in women is early in the endocrine aging process.

Source: Neurology - September 25, 2017 Category: Neurology Authors: Mosconi, L., Berti, V., Quinn, C., McHugh, P., Petrongolo, G., Varsavsky, I., Osorio, R. S., Pupi, A., Vallabhajosula, S., Isaacson, R. S., de Leon, M. J., Brinton, R. D. Tags: PET, Alzheimer's disease, Cognitive aging ARTICLE Source Type: research